Department of Medical Oncology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, No. 758 Hefei Road, Qingdao, Shandong 266035, China.
Department of Radiation Oncology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, No. 758 Hefei Road, Qingdao 266035, China.
Hum Immunol. 2024 Sep;85(5):111087. doi: 10.1016/j.humimm.2024.111087. Epub 2024 Aug 16.
Lung cancer, characterized by its high incidence and mortality rates, is a challenging malignancy to treat. Immunotherapy has emerged as a crucial treatment modality, yet its effectiveness varies significantly among patients due to the diverse immune microenvironment involved. Our study aims to analyze the similarities and differences in immune cell profiles across different subtypes of lung cancer. We employed a comprehensive two-sample Mendelian randomization analysis to establish causal connections between immune cells and lung cancer. We examined differential expression of 731 immune cell types and compared their profiles among various lung cancer subtypes. Our analysis revealed that 47 immune cell types exhibited differential expression in lung cancer, with 15 showing a protective effect and 32 having a tumor-promoting effect. Notably, we observed greater similarities in immune cell profile between squamous carcinoma and adenocarcinoma subtypes, while small cell lung cancerHHHH displayed less overlap with the other two types. Specifically, CD4+ naive T cells showed differential expression across all three lung cancer subtypes, whereas three other immune cell types exhibited differential expression exclusively in adenocarcinoma and squamous cell carcinoma. Our findings substantiate a causal link between immune cell dynamics and lung cancer progression. Moreover, our identification of distinct immune cell composition among histological subtypes of lung cancer may serve as a valuable reference for further investigation into immunotherapeutic strategies.
肺癌具有发病率和死亡率高的特点，是一种难以治疗的恶性肿瘤。免疫疗法已成为一种重要的治疗方式，但由于涉及到不同的免疫微环境，其在患者中的疗效差异很大。我们的研究旨在分析不同亚型肺癌之间免疫细胞谱的异同。我们采用全面的两样本 Mendelian 随机分析来建立免疫细胞与肺癌之间的因果关系。我们检查了 731 种免疫细胞类型的差异表达，并比较了它们在不同肺癌亚型中的分布。我们的分析表明，肺癌中有 47 种免疫细胞类型表现出差异表达，其中 15 种具有保护作用，32 种具有促进肿瘤的作用。值得注意的是，我们观察到鳞状细胞癌和腺癌亚型之间的免疫细胞谱更为相似，而小细胞肺癌与其他两种类型的重叠较少。具体来说，CD4+幼稚 T 细胞在所有三种肺癌亚型中均表现出差异表达，而另外三种免疫细胞类型仅在腺癌和鳞状细胞癌中表现出差异表达。我们的研究结果证实了免疫细胞动态与肺癌进展之间的因果关系。此外，我们在肺癌的组织学亚型中发现了不同的免疫细胞组成，这可能为进一步研究免疫治疗策略提供有价值的参考。
