Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China.
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China.
Biomed Pharmacother. 2024 Oct;179:117272. doi: 10.1016/j.biopha.2024.117272. Epub 2024 Aug 18.
Calpain, a key member of the Calpain cysteine protease superfamily, performs limited protein hydrolysis in a calcium-dependent manner. Its activity is tightly regulated due to the potential for non-specific cleavage of various intracellular proteins upon aberrant activation. A thorough review of the literature from 2010 to 2023 reveals 121 references discussing cardiovascular and cerebrovascular diseases. Dysregulation of the Calpain system is associated with various pathological phenomena, including lipid metabolism disorders, inflammation, apoptosis, and excitotoxicity. Although recent studies have revealed the significant role of Calpain in cardiovascular and cerebrovascular diseases, the precise mechanisms remain incompletely understood. Exploring the potential of Calpain inhibition as a therapeutic approach for the treatment of cardiovascular and cerebrovascular diseases may emerge as a compelling area of interest for future calpain research.
钙蛋白酶，钙蛋白酶半胱氨酸蛋白酶超家族的关键成员，以钙离子依赖的方式进行有限的蛋白质水解。由于异常激活时可能会非特异性地切割各种细胞内蛋白，因此其活性受到严格调节。对 2010 年至 2023 年的文献进行全面回顾，发现有 121 篇参考文献讨论了心血管和脑血管疾病。钙蛋白酶系统的失调与各种病理现象有关，包括脂质代谢紊乱、炎症、细胞凋亡和兴奋毒性。尽管最近的研究揭示了钙蛋白酶在心血管和脑血管疾病中的重要作用，但确切的机制仍不完全清楚。探索钙蛋白酶抑制作为治疗心血管和脑血管疾病的一种治疗方法的潜力可能成为未来钙蛋白酶研究的一个引人关注的领域。
