Department of Spine Surgery, Ganzhou People's Hospital, 16 Meiguan Avenue, Ganzhou, Jiangxi Province 341000, PR China; Department of Spine Surgery, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou Hospital-Nanfang Hospital, Southern Medical University), 16 Meiguan Avenue, Ganzhou, Jiangxi Province 341000, PR China.
Department of Spine Surgery, Ganzhou People's Hospital, 16 Meiguan Avenue, Ganzhou, Jiangxi Province 341000, PR China; Department of Spine Surgery, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou Hospital-Nanfang Hospital, Southern Medical University), 16 Meiguan Avenue, Ganzhou, Jiangxi Province 341000, PR China.
Biomed Pharmacother. 2024 Oct;179:117306. doi: 10.1016/j.biopha.2024.117306. Epub 2024 Aug 16.
Spinal cord injury (SCI) is a central nervous system injury that leads to neurological dysfunction or paralysis, which seriously affects patients' quality of life and causes a heavy social and economic burden. The pathological mechanism of SCI has not been fully revealed, resulting in unsatisfactory clinical treatment. Therefore, more research is urgently needed to reveal its precise pathological mechanism. Numerous studies have shown that inflammation is closely related to various pathological processes in SCI. Inflammatory response is an important pathological process leading to secondary injury, and sustained inflammatory response can exacerbate the injury and hinder the recovery of neurological function after injury. Epigenetic modification is considered to be an important regulatory mechanism in the pathological process of many diseases. Epigenetic modification mainly affects the function and characteristics of genes through the reversibility of mechanisms such as DNA methylation, histone modification, and regulation of non-coding RNA, thus having a significant impact on the pathological process of diseases and the survival state of the body. Recently, the role of epigenetic modification in the inflammatory response of SCI has gradually entered the field of view of researchers, and epigenetic modification may be a potential means to treat SCI. In this paper, we review the effects and mechanisms of different types of epigenetic modifications (including histone modifications, DNA methylation, and non-coding RNAs) on post-SCI inflammation and their potential therapeutic effects on inflammation to improve our understanding of the secondary SCI stage. This review aims to help identify new markers, signaling pathways and targeted drugs, and provide theoretical basis and new strategies for the diagnosis and treatment of SCI.
脊髓损伤（SCI）是一种中枢神经系统损伤，导致神经功能障碍或瘫痪，严重影响患者的生活质量，并造成沉重的社会和经济负担。SCI 的病理机制尚未完全揭示，导致临床治疗效果不尽人意。因此，迫切需要更多的研究来揭示其精确的病理机制。大量研究表明，炎症与 SCI 的各种病理过程密切相关。炎症反应是导致继发性损伤的重要病理过程，持续的炎症反应会加重损伤，并阻碍损伤后神经功能的恢复。表观遗传修饰被认为是许多疾病病理过程中的重要调节机制。表观遗传修饰主要通过 DNA 甲基化、组蛋白修饰和非编码 RNA 调控等机制的可逆性来影响基因的功能和特征，从而对疾病的病理过程和机体的生存状态产生重大影响。最近，表观遗传修饰在 SCI 炎症反应中的作用逐渐引起了研究人员的关注，表观遗传修饰可能是治疗 SCI 的一种潜在手段。本文综述了不同类型的表观遗传修饰（包括组蛋白修饰、DNA 甲基化和非编码 RNA）对 SCI 后炎症的作用及其对炎症的潜在治疗效果，以提高我们对继发性 SCI 阶段的认识。本综述旨在帮助确定新的标记物、信号通路和靶向药物，并为 SCI 的诊断和治疗提供理论基础和新策略。
