Department of Neurology, Hangzhou Traditional Chinese Medicine Hospital affiliated to Zhejiang Chinese Medical University, 453# Tiyuchang Road, Hangzhou 310007, China.
Department of Neurology, Hangzhou Traditional Chinese Medicine Hospital affiliated to Zhejiang Chinese Medical University, 453# Tiyuchang Road, Hangzhou 310007, China.
J Stroke Cerebrovasc Dis. 2024 Nov;33(11):107944. doi: 10.1016/j.jstrokecerebrovasdis.2024.107944. Epub 2024 Aug 15.
The purpose of this study is to the relationship between peripheral apolipoproteins and the prognosis of patients with acute ischemic stroke (AIS) after thrombolysis.
A total of 231 AIS patients with thrombolysis was enrolled. Serum apolipoproteins were measured on admission after thrombolysis. All patients enrolled were followed up for 90 days. Their functional outcomes were assessed by the modified Rankin Scale (mRS). Good functional outcome was considered as mRS < 3. Logistic regression was applied to assess the association between serum apolipoproteins and the mRS at 90 days.
In multivariate analysis,1) ApoB (OR=0.099, 95%CI=0.017∼0.575, p=0.010) and ApoB/ApoA-1(OR=0.113, 95%CI=0.015∼0.868, p=0.036) were independent risk factors of good functional outcome at 90 days. 2). there were significant differences in the mRS score distribution at 90 days in groups according to the ROC cutoff values of ApoB (0.85g/L) and ApoB/ApoA-1 ratio (0.61) (all p<0.05).
Our findings demonstrated ApoB and ApoB/apoA-1 ratio were independent risk factors for good functional outcome at 90 days, and the ApoB level below 0.85g/L and ApoB/ApoA-1 ratio below 0.61 could be associated with a better functional outcome in this study population.
本研究旨在探讨急性缺血性脑卒中（AIS）溶栓后外周载脂蛋白与患者预后的关系。
共纳入 231 例接受溶栓治疗的 AIS 患者。溶栓后入院时检测血清载脂蛋白。所有入组患者均进行 90 天随访，采用改良 Rankin 量表（mRS）评估其功能结局。良好的功能结局定义为 mRS<3。采用 logistic 回归评估血清载脂蛋白与 90 天 mRS 的关系。
在多变量分析中，1）ApoB（OR=0.099，95%CI=0.017∼0.575，p=0.010）和 ApoB/ApoA-1（OR=0.113，95%CI=0.015∼0.868，p=0.036）是 90 天良好功能结局的独立危险因素。2）根据 ApoB（0.85g/L）和 ApoB/ApoA-1 比值（0.61）的 ROC 截断值，90 天时 mRS 评分分布在各组间存在显著差异（均 p<0.05）。
本研究结果表明，ApoB 和 ApoB/ApoA-1 比值是 90 天良好功能结局的独立危险因素，ApoB 水平低于 0.85g/L 和 ApoB/ApoA-1 比值低于 0.61 可能与该研究人群的更好功能结局相关。
