Medical Record and Statistic Department, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China.
Laboratory Animal Center, Shanxi Provincial Peoples Hospital, Taiyuan, Shanxi, China.
BMJ Open. 2024 Aug 17;14(8):e081485. doi: 10.1136/bmjopen-2023-081485.
To seek a triple combination of biomarkers for early diagnosis of chronic kidney disease-mineral and bone metabolic disorder and to explore the diagnostic efficacy of β2-microglobulin, parathyroid hormone and blood urea nitrogen in chronic kidney disease-mineral and bone metabolic disorder.
We collected medical records of 864 patients with chronic kidney disease (without direct contact with patients) and divided them into two groups based on the renal bone disease manifestations of all patients.
There were 148 and 716 subjects in the Chronic kidney disease-mineral and bone metabolic disorder and the control groups, respectively. The aggregated data included basic information and various clinical laboratory indicators, such as blood lipid profile, antibody and electrolyte levels, along with renal function-related indicators.
It was observed that most renal osteopathy occurs in the later stages of chronic kidney disease. In the comparison of two clinical laboratory indicators, 16 factors were selected for curve analysis and compared. We discovered that factors with high diagnostic values were β2-microglobulin, parathyroid hormone and blood urea nitrogen.
The triple combination of β2-microglobulin+parathyroid hormone+blood urea nitrogen indicators can play the crucial role of a sensitive indicator for the early diagnosis of chronic kidney disease-mineral and bone metabolic disorder and in preventing or delaying the progress of chronic kidney disease-mineral and bone metabolic disorder.
寻找用于早期诊断慢性肾脏病-矿物质和骨代谢紊乱的三联生物标志物，并探讨β2-微球蛋白、甲状旁腺激素和血尿素氮在慢性肾脏病-矿物质和骨代谢紊乱中的诊断效能。
我们收集了 864 例慢性肾脏病患者的病历（未直接接触患者），并根据所有患者的肾性骨病表现将其分为两组。
慢性肾脏病-矿物质和骨代谢紊乱组和对照组分别有 148 例和 716 例患者。汇总数据包括基本信息和各种临床实验室指标，如血脂谱、抗体和电解质水平以及肾功能相关指标。
观察到大多数肾性骨病发生在慢性肾脏病的晚期。在比较两种临床实验室指标时，选择了 16 个因素进行曲线分析和比较。我们发现具有高诊断价值的因素是β2-微球蛋白、甲状旁腺激素和血尿素氮。
β2-微球蛋白+甲状旁腺激素+血尿素氮指标的三联组合可以作为慢性肾脏病-矿物质和骨代谢紊乱早期诊断的敏感指标，有助于预防或延缓慢性肾脏病-矿物质和骨代谢紊乱的进展。
