血小板计数、高密度脂蛋白胆固醇、血小板/高密度脂蛋白胆固醇比值与血清可溶性 Klotho 的关系。
The association of platelet count, high-density lipoprotein cholesterol, and platelet/high-density lipoprotein cholesterol ratio with serum soluble Klotho.
机构信息
Department of Hematology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, No.636 Guanlin Road, Luolong District, Luoyang City, Henan Province, China.
Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zheng zhou, China.
出版信息
Lipids Health Dis. 2024 Aug 17;23(1):251. doi: 10.1186/s12944-024-02242-6.
BACKGROUND AND OBJECTIVE
Klotho is a protein that is closely related to human aging. Soluble Klotho (S-Klotho) is a circulating protein, and its level decreases in response to systemic inflammation. The relationship between the platelet/high-density lipoprotein cholesterol ratio (PHR), an emerging inflammatory index, and S-Klotho concentrations is still unclear. In addition, the mean platelet volume has been confirmed to have a significant negative association with S-Klotho concentrations, but the relationship between the platelet count (PC) and S-Klotho concentrations has not yet been reported.
METHODS
Data from individuals who participated in the National Health and Nutrition Examination Survey (NHANES) during the five cycles from 2007 to 2016 were retrieved for analysis. Linear regression, two-piecewise linear regression, and restricted cubic spline (RCS) methods were used to analyze the associations of the PHR index and its components with S-Klotho concentrations. In addition, subgroup analysis and effect modification tests were conducted.
RESULTS
A total of 11,123 participants (5463 men (48.17%)), with an average age of 56.2 years, were included. After full adjustment, the S-Klotho levels of participants in the highest quartile group of PHR (β: -51.19, 95% CI: -75.41 to -26.97, P < 0.001) and the highest quartile group of PC (β: -72.34, 95% CI: -93.32 to -51.37, P < 0.0001) were significantly lower than those in their respective lowest quartile groups, and a significant downward trend was presented among the four groups (P for trend < 0.05, respectively). However, high-density lipoprotein cholesterol (HDL-C) concentrations were not significantly associated with S-Klotho concentrations. RCS revealed that the PHR and PC were nonlinearly associated with S-Klotho concentrations; two-piecewise linear regression revealed that the inflection points were 175.269 and 152, respectively, and that these associations slightly weakened after the inflection point. According to the subgroup analysis, liver disease status enhanced the association between the PC and S-Klotho concentrations.
CONCLUSIONS
Both the PHR and PC were significantly negatively associated with S-Klotho concentrations, and these associations were nonlinear. There was no significant association between HDL-C and S-Klotho concentrations. Liver disease status enhances the negative association between the PC and S-Klotho concentrations, and the specific mechanism deserves further exploration.
背景与目的
Klotho 是一种与人类衰老密切相关的蛋白质。可溶性 Klotho（S-Klotho）是一种循环蛋白，其水平会随全身炎症反应而降低。血小板/高密度脂蛋白胆固醇比值（PHR）作为一种新兴的炎症指标，与 S-Klotho 浓度之间的关系尚不清楚。此外，已有研究证实平均血小板体积与 S-Klotho 浓度呈显著负相关，但血小板计数（PC）与 S-Klotho 浓度之间的关系尚未见报道。
方法
检索了 2007 年至 2016 年五个周期参加国家健康和营养检查调查（NHANES）的个体数据进行分析。采用线性回归、两段线性回归和限制性立方样条（RCS）方法分析 PHR 指数及其成分与 S-Klotho 浓度之间的关系。此外，还进行了亚组分析和效应修饰检验。
结果
共纳入 11123 名参与者（男性 5463 名（48.17%）），平均年龄为 56.2 岁。经完全校正后，PHR 最高四分位组（β：-51.19，95%CI：-75.41 至-26.97，P<0.001）和 PC 最高四分位组（β：-72.34，95%CI：-93.32 至-51.37，P<0.0001）的 S-Klotho 水平显著低于各自最低四分位组，且四组间呈显著下降趋势（P 趋势<0.05）。然而，高密度脂蛋白胆固醇（HDL-C）浓度与 S-Klotho 浓度无显著相关性。RCS 显示 PHR 和 PC 与 S-Klotho 浓度呈非线性相关；两段线性回归显示，拐点分别为 175.269 和 152，拐点后这些关联略有减弱。根据亚组分析，肝脏疾病状态增强了 PC 与 S-Klotho 浓度之间的关联。
结论
PHR 和 PC 与 S-Klotho 浓度均呈显著负相关，且呈非线性关系。HDL-C 与 S-Klotho 浓度无显著相关性。肝脏疾病状态增强了 PC 与 S-Klotho 浓度之间的负相关，具体机制值得进一步探讨。
Zotero 插件