Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Second Road, Shanghai, 200025, China.
Sci Rep. 2024 Aug 17;14(1):19079. doi: 10.1038/s41598-024-68962-y.
Not all patients with glioblastoma multiforme (GBM) eligible for systemic chemotherapy after upfront surgery and radiotherapy finally receive it. The information on patients with GBM was retrieved from the surveillance, epidemiology, and end results database. Patients who underwent upfront surgery or biopsy and external beam radiotherapy between 2010 and 2019 were eligible for systemic chemotherapy. The available patient and tumor characteristics were assessed using multivariable logistic regression and chi-squared test. Out of the 16,682 patients eligible, 92.1% underwent systemic chemotherapy. The characteristics linked to the lowest systemic chemotherapy utilization included tumors of the brain stem/cerebellum (P = 0.01), former years of diagnosis (P = 0.001), ≥ 80 years of age (P < 0.001), Hispanic, Non-Hispanic Asian, Pacific Islander, or Black race (P < 0.001), non-partnered status (P < 0.001), and low median household income (P = 0.006). Primary tumor site, year of diagnosis, age, race, partnered status, and median household income correlated with the omission of systemic chemotherapy in GBM in adult patients.
并非所有适合在 upfront 手术和放疗后接受全身化疗的多形性胶质母细胞瘤 (GBM) 患者最终都接受了化疗。GBM 患者的信息是从监测、流行病学和最终结果数据库中检索出来的。2010 年至 2019 年间接受 upfront 手术或活检和外照射放疗的患者有资格接受全身化疗。使用多变量逻辑回归和卡方检验评估了患者和肿瘤的特征。在 16682 名符合条件的患者中，92.1%接受了全身化疗。与最低全身化疗利用率相关的特征包括脑干/小脑肿瘤（P=0.01）、前几年诊断（P=0.001）、≥80 岁（P<0.001）、西班牙裔、非西班牙裔亚裔、太平洋岛民或黑人种族（P<0.001）、非伴侣状态（P<0.001）和低收入家庭中位数（P=0.006）。原发性肿瘤部位、诊断年份、年龄、种族、伴侣状况和家庭中位数收入与成年 GBM 患者全身化疗的遗漏有关。
