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酒精使用障碍的康复:强化物病理学理论、测量方法及手段

Recovery from alcohol use disorder: Reinforcer pathology theory, measurement, and methods.

作者信息

Bickel Warren K, Witkiewitz Katie, Athamneh Liqa N, Kuhlemeier Alena

机构信息

Addiction Recovery Research Center, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.

University of New Mexico, Albuquerque, New Mexico, USA.

出版信息

Alcohol Clin Exp Res (Hoboken). 2024 Sep;48(9):1626-1636. doi: 10.1111/acer.15406. Epub 2024 Aug 18.

Abstract

Recovery from alcohol use disorder (AUD) is a dynamic process that often entails periods of drinking but has been defined primarily by abstinence. Recently, a broader interpretation of recovery was developed, including meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM) remission criteria and improved psychosocial functioning. This new understanding of recovery has facilitated the development of novel theories and methodologies. This paper reviews a new theoretical perspective of recovery, Reinforcer Pathology, and two novel methodological approaches in light of this broader view of recovery. Using this theoretical framework as a foundation, we propose an alternative perspective to explain the recovery process as it relates to environmental factors and valuation of the future; we suggest that changing the environment in which substances are available (e.g., increasing non-alcohol-related activities) and extending one's temporal window are associated with improved recovery outcomes (e.g., remission and quality of life). In this review, we discuss two novel methodological approaches. The first uses latent profile analysis to show that using a measure of Relative Reinforcement Value of Alcohol-Free Activities is associated with a greater likelihood of belonging to a high functioning/infrequent heavy drinking recovery profile. The second developed an online national sample and used an accelerated longitudinal design to study longer-term recovery of up to 12 years over a 5-year study period. Reinforcer Pathology theory, novel methods, and measures may further our understanding of recovery and begin to address critical questions for future studies. Subsequent randomized clinical trials should examine whether the suggested targets and interventions based on the theoretical model improve recovery outcomes prospectively. Measuring and promoting alcohol-free activity engagement may facilitate improved recovery outcomes, while novel methodologies permit an understanding of returning to use or remission across different recovery durations.

摘要

从酒精使用障碍(AUD)中恢复是一个动态过程,通常需要经历饮酒阶段,但主要以戒酒来定义。最近,人们对恢复有了更广泛的解读,包括符合《精神疾病诊断与统计手册》(DSM)的缓解标准以及改善心理社会功能。这种对恢复的新理解推动了新理论和方法的发展。本文根据对恢复的这一更广泛观点,回顾了一种关于恢复的新理论视角——强化物病理学,以及两种新的方法学途径。以这个理论框架为基础,我们提出了另一种视角来解释与环境因素和未来价值评估相关的恢复过程;我们认为,改变物质可得的环境(例如,增加与酒精无关的活动)以及延长个人的时间跨度与改善恢复结果(例如,缓解和生活质量)相关。在这篇综述中,我们讨论了两种新的方法学途径。第一种使用潜在剖面分析表明,使用无酒精活动的相对强化价值测量方法与属于高功能/不频繁重度饮酒恢复剖面的可能性更大相关。第二种方法建立了一个全国在线样本,并采用加速纵向设计来研究在5年研究期内长达12年的长期恢复情况。强化物病理学理论、新方法和测量手段可能会加深我们对恢复的理解,并开始解决未来研究的关键问题。后续的随机临床试验应前瞻性地检验基于理论模型提出的目标和干预措施是否能改善恢复结果。测量和促进无酒精活动参与可能有助于改善恢复结果,而新方法学能让我们了解在不同恢复阶段的复饮或缓解情况。

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