Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
Department of Ophthalmology, Hospital Selayang, Batu Caves, Malaysia.
Korean J Ophthalmol. 2024 Oct;38(5):364-374. doi: 10.3341/kjo.2024.0048. Epub 2024 Aug 16.
There has been a lack of data on health-related quality of life (HRQoL) in children with vernal keratoconjunctivitis (VKC) from Southeast Asia. This study evaluated the levels (mean total score and subscales score) of HRQoL, comparing the VKC and normal children groups, and within the VKC severity groups.
A cross-sectional study was conducted in two tertiary hospitals, specifically the pediatric ophthalmology services at Hospital Selayang and Universiti Sains Malaysia, spanning from 2019 to 2020. Participants aged between 8 and 15 years were categorized into two groups: those diagnosed with VKC and healthy children serving as the control group. Each participant completed the Quality of Life in Children with Vernal Keratoconjunctivitis (QUICK) questionnaire, consisting of 16 questions, divided into two subscales: 12 questions focusing on symptoms and four questions for daily activities.
A total of 240 children took part in the study, with 120 children diagnosed with VKC and another 120 in the control group. The mean age of participants with VKC was 11.21 ± 1.91 years, with a male predominance of 4:1 compared to female. Tearing (98.4%) and itchiness (98.3%) emerged as the most prevalent symptoms affecting HRQoL, while the most challenging activities were outdoor play (36.6%) and participation in recreational water activities (34.2%). The mean total score was significantly higher in the VKC group compared to the control group. Additionally, both the mean total score and all subscale scores were significantly higher in the severe type compared to the mild-moderate type.
VKC significantly reduce the HRQoL among Malaysian children, and the negative impact increases with the disease severity.
东南亚地区针对春季角结膜炎（VKC）患儿健康相关生活质量（HRQoL）的数据较少。本研究评估了 HRQoL 的水平（总分均值和各分量表得分），比较了 VKC 组和正常儿童组以及 VKC 严重程度组之间的差异。
本研究为 2019 年至 2020 年在塞拉央医院和马来西亚理科大学的儿科眼科服务处进行的横断面研究。参与者年龄在 8 至 15 岁之间，分为两组：一组被诊断为 VKC，另一组为健康儿童作为对照组。每位参与者都完成了《儿童春季角结膜炎生活质量问卷》（QUICK），共 16 个问题，分为两个分量表：12 个问题集中于症状，4 个问题用于日常活动。
共有 240 名儿童参与了研究，其中 120 名被诊断为 VKC，对照组有 120 名。VKC 患儿的平均年龄为 11.21 ± 1.91 岁，男性与女性的比例为 4:1。流泪（98.4%）和瘙痒（98.3%）是影响 HRQoL 的最常见症状，而最具挑战性的活动是户外活动（36.6%）和参与娱乐性水上活动（34.2%）。VKC 组的总分均值明显高于对照组。此外，严重型的总分均值和所有分量表得分均明显高于轻-中型。
VKC 显著降低了马来西亚儿童的 HRQoL，且疾病严重程度越高，负面影响越大。
