Tsai Chi-Neu, Chang Yu-Chung, Chao Hsun-Ching, Hsu Yi-Hsiang, Wang Yuan-Hung, Chen Shih-Yen
Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Department of Biotechnology, Ming-Chuan University, Taoyuan, Taiwan.
J Formos Med Assoc. 2025 Feb;124(2):186-189. doi: 10.1016/j.jfma.2024.07.024. Epub 2024 Aug 17.
Norovirus (NoV) has been an emerging pathogen of enteric infections in the post-rotavirus vaccine era. GII.4 have played a major role in NoV infections while other genotypes were reported in sporadic outbreaks. In this study, we reported novel variant NoV GII.12 outbreaks in 2010, Taiwan with their genomic analysis and clinical manifestations compared to GII.4 infections. There were 30.5% (29 out of 95 cases) with NoV infection. The most common genotype was GII.4 (22, 75.9%) followed by GII.12 (5, 17.2%) and GII.3 (2, 6.9%). Phylogenetic analysis showed that our GII.12 sequences were closely aligned with reference genomes identified in the United Kingdom and the United States of America. When compared to patients infected by GII.4 NoV, those with GII.12 infection experienced a lower frequency and shorter duration of diarrhea. Continued research is essential to unravel the intricate relationship between NoV genotypes and clinical outcomes, guiding public health interventions and therapeutic strategies.
在轮状病毒疫苗时代之后，诺如病毒（NoV）已成为肠道感染的一种新兴病原体。GII.4在诺如病毒感染中起主要作用，而其他基因型则在散发性疫情中被报道。在本研究中，我们报告了2010年台湾地区新型变异诺如病毒GII.12的暴发，并将其基因组分析和临床表现与GII.4感染进行了比较。95例病例中有30.5%（29例）感染了诺如病毒。最常见的基因型是GII.4（22例，75.9%），其次是GII.12（5例，17.2%）和GII.3（2例，6.9%）。系统发育分析表明，我们的GII.12序列与在英国和美国鉴定的参考基因组密切对齐。与感染GII.4诺如病毒的患者相比，感染GII.12的患者腹泻频率较低，持续时间较短。持续的研究对于揭示诺如病毒基因型与临床结果之间的复杂关系至关重要，可为公共卫生干预措施和治疗策略提供指导。
