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[2021至2022年北京体育大学新生高尿酸血症的患病率及危险因素]

[Prevalence and risk factors of hyperuricemia among freshmen at Beijing Sport University from 2021 to 2022].

作者信息

Yu Wenlang, Wang Wenxing, Zhao Yuanhui, Lin Fangping, Zhang Shichao, Peng Jiale, Ge Yongwei, Chen Yanzhong, Ren Hong

机构信息

College of Sports Human Sciences, Beijing Sport University, Beijing 100084, China.

College of Sports Human Sciences, Beijing Sport University, Beijing 100084, China Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing 100084, China.

出版信息

Wei Sheng Yan Jiu. 2024 Jul;53(4):592-607. doi: 10.19813/j.cnki.weishengyanjiu.2024.04.011.

DOI:10.19813/j.cnki.weishengyanjiu.2024.04.011
PMID:39155227
Abstract

OBJECTIVE

To investigate the prevalence of hyperuricemia among freshmen enrolled in Beijing Sport University and to explore the influencing factors of hyperuricemia in the college population.

METHODS

The study period was from September 2021 to February 2022.3372 freshmen of the class of 2021 from Beijing Sport University in Beijing were selected as the study subjects, and two blood uric acid tests were performed on non-same days to calculate the prevalence of the population and to explore the risk factors of hyperuricemia in the college student population using a case-control method.246 people were selected from the hyperuricemia patients of the population to be included in the case group by convenience sampling, and 211 people were selected from the non-hyperuricemia persons of the population to be included in the control group. They were included in the control group, underwent physical and laboratory examinations, and were retrospectively surveyed with questionnaires that included general information such as age, gender, specialty, place of birth, and diet related to hyperuricemia, awareness of hyperuricemia disease, physical activity level, and sleep. Statistical analysis was performed using chi-square analysis, one-way Logistic regression analysis, and multi-factor logistic regression analysis.

RESULTS

The number of patients actually diagnosed with hyperuricemia by two blood uric acid tests on non-same days was 479, with a population prevalence rate of 14.21%. Among them, the number of males in the diseased population was 391(22.39%), and the number of females in the diseased population was 88(5.41%). A total of 457 subjects were enrolled in the case-control study, among them, 246 in the case group(218 males and 28 females, average age 19.74 years), 211 in the control group(177 males and 34 females, average age 19.93 years), and 247 in the case group, 211 in the control group, and 2 groups of subjects were included. A total of 211 subjects, and there was no significant difference between the 2 groups in terms of gender composition and age distribution. One-way logistic regression analysis showed that central obesity(OR=31.52, 95%CI 7.59-130.86), obesity(OR=2.59, 95%CI 1.20-5.58), overweight(OR=1.67, 95%CI 1.08-2.59), frequent consumption of fresh vegetables(OR=0.66, 95%CI 0.43-0.99), and drinking 1500-2000 mL of water per day(OR=0.63, 95%CI 0.41-0.95) were associated with hyperuricemia, and multifactorial Logistic regression analyses were performed to analyze the above factors, and finally central obesity(OR=32.05, 95%CI 7.65-134.20), BMI obesity(OR=3.22, 95%CI 1.44-7.20), and daily water intake of 1500-2000 mL(OR=0.60, 95%CI 0.37-0.95) were included in the model at the level of P=0.05.

CONCLUSION

The current high prevalence of hyperuricemia in the college student population, which is more prevalent in male college students. Obesity and central obesity are risk factors for hyperuricemia in young college students, and daily water intake of 1500-2000 mL is a protective factor.

摘要

目的

调查北京体育大学新生高尿酸血症的患病率,并探讨高校人群高尿酸血症的影响因素。

方法

研究时间为2021年9月至2022年2月。选取北京体育大学2021级3372名新生作为研究对象,在不同日期进行两次血尿酸检测,计算人群患病率,并采用病例对照法探讨大学生人群高尿酸血症的危险因素。通过方便抽样从人群中的高尿酸血症患者中选取246人纳入病例组,从人群中的非高尿酸血症者中选取211人纳入对照组。对其进行体格检查和实验室检查,并通过问卷进行回顾性调查,问卷内容包括年龄、性别、专业、出生地等一般信息以及与高尿酸血症相关的饮食、对高尿酸血症疾病的知晓情况、身体活动水平和睡眠情况。采用卡方分析、单因素Logistic回归分析和多因素Logistic回归分析进行统计分析。

结果

不同日期两次血尿酸检测实际诊断为高尿酸血症的患者人数为479人,人群患病率为14.21%。其中,患病群体中男性391人(22.39%),女性88人(5.41%)。病例对照研究共纳入457名受试者,其中病例组246人(男性218人,女性28人,平均年龄19.74岁),对照组211人(男性177人,女性34人,平均年龄19.93岁),两组受试者纳入247人,对照组211人。两组在性别构成和年龄分布方面无显著差异。单因素Logistic回归分析显示,中心性肥胖(OR=31.52,95%CI 7.59-130.86)、肥胖(OR=2.59,95%CI 1.20-5.58)、超重(OR=1.67,95%CI 1.08-2.59)、经常食用新鲜蔬菜(OR=0.66,95%CI 0.43-0.99)以及每日饮水1500-2000 mL(OR=0.63,95%CI 0.41-0.95)与高尿酸血症有关,对上述因素进行多因素Logistic回归分析,最终在P=0.05水平将中心性肥胖(OR=32.05,95%CI 7.65-134.20)、BMI肥胖(OR=3.22,95%CI 1.44-7.20)和每日饮水1500-2000 mL(OR=0.60,95%CI 0.37-0.95)纳入模型。

结论

当前大学生人群高尿酸血症患病率较高,在男大学生中更为普遍。肥胖和中心性肥胖是青年大学生高尿酸血症的危险因素,每日饮水1500-2000 mL是保护因素。

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