Universite de Bordeaux, INSERM, U1215 Neurocentre Magendie, Bordeaux, France.
Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Nat Commun. 2024 Aug 18;15(1):7103. doi: 10.1038/s41467-024-51416-4.
Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning.
情绪和行为可能会受到来自同种动物的社会化学信号的影响。例如，来自压力大的个体的嗅觉信号会导致天真的伴侣产生类似压力的生理和突触变化。直接的压力也会改变认知，但社会传递的压力对记忆过程的影响目前尚不清楚。在这里，我们表明，暴露于来自压力大的个体的化学信号足以损害未受压力的雄性小鼠的记忆检索。这需要星形胶质细胞通过与线粒体相关的 CB1 受体 (mtCB1) 来控制嗅球中的信息。靶向基因操作、体内 Ca 成像和行为分析表明，mtCB1 依赖性线粒体 Ca 动力学控制对于处理来自压力大的伴侣的嗅觉信息以及定义其认知后果是必要的。因此，嗅球星形胶质细胞为社交气味及其行为意义之间提供了联系。
