Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Department of Agricultural Chemistry, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.
J Agric Food Chem. 2024 Sep 4;72(35):19517-19525. doi: 10.1021/acs.jafc.4c05797. Epub 2024 Aug 18.
Strigolactones (SLs) are plant hormones that regulate shoot branching. In addition, SLs act as compounds that stimulate the germination of root parasitic weeds, such as spp. and spp., which cause significant damage to agriculture worldwide. Thus, SL agonists have the potential to induce suicidal germination, thereby reducing the seed banks of root parasitic weeds in the soil. Particularly, phenoxyfuranone-type SL agonists, known as debranones, exhibit SL-like activity in rice and . However, little is known about their effects on spp. In this study, we evaluated the germination-inducing activity of debranones against . Analysis of structure-activity relationships revealed that debranones with electron-withdrawing substituents at the 2,4- or 2,6-position strongly induced the germination of . Lastly, biological assays indicated that 5-(2-fluoro-4-nitrophenoxy)-3-methylfuran-2(5)-one (test compound ) induced germination to a comparable or even stronger extent than GR24, a well-known synthetic SL. Altogether, our data allowed us to infer that this enhanced activity was due to the recognition of compound by the SLs receptor, KAI 2d, in .
独脚金内酯（SLs）是一类植物激素，调控着侧芽分枝。此外，SLs 作为化合物可以刺激根寄生杂草（如独脚金属和列当属）的萌发，而这些杂草会对全球农业造成严重损害。因此，SL 激动剂具有诱导自杀性萌发的潜力，从而减少土壤中根寄生杂草的种子库。特别是，苯氧呋喃酮型 SL 激动剂，被称为去甲独脚金内酯，在水稻和拟南芥中表现出类似 SL 的活性。然而，关于它们对列当属的影响知之甚少。在这项研究中，我们评估了去甲独脚金内酯对列当属的萌发诱导活性。结构-活性关系分析表明，在 2,4-或 2,6-位具有吸电子取代基的去甲独脚金内酯强烈诱导列当属的萌发。最后，生物测定表明，5-(2-氟-4-硝基苯氧基)-3-甲基呋喃-2(5)-酮（测试化合物）的诱导萌发程度与 GR24（一种著名的合成 SL）相当，甚至更强。总的来说，我们的数据表明，这种增强的活性是由于化合物被 SL 受体 KAI2d 识别所致。
