Sun Haijun, Chen Meixia, Liao Jialong, He Linjuan, Wan Boyang, Yin Jingdong, Zhang Xin
State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
J Cachexia Sarcopenia Muscle. 2024 Oct;15(5):1641-1650. doi: 10.1002/jcsm.13556. Epub 2024 Aug 18.
The world is facing a global nutrition crisis, as evidenced by the rising incidence of metabolic disorders such as obesity, insulin resistance and chronic inflammation. Skeletal muscle is the largest tissue in humans and plays an important role in movement and host metabolism. Muscle fibre formation occurs mainly during the embryonic stage. Therefore, maternal lifestyle, especially nutrition and exercise during pregnancy, has a critical influence on foetal skeletal muscle development and the subsequent metabolic health of the offspring. In this review, the influence of maternal obesity, malnutrition and micronutrient intake on foetal skeletal muscle development is systematically summarized. We also aim to describe how maternal exercise shapes foetal muscle development and metabolic health in the offspring. The role of maternal gut microbiota and its metabolites on foetal muscle development is further discussed, although this field is still in its 'infancy'. This review will provide new insights to reduce the global crisis of metabolic disorders and highlight current gaps to promote further research.
世界正面临全球营养危机，肥胖、胰岛素抵抗和慢性炎症等代谢紊乱发病率不断上升就是明证。骨骼肌是人体最大的组织，在运动和机体代谢中发挥着重要作用。肌纤维形成主要发生在胚胎期。因此，母亲的生活方式，尤其是孕期的营养和运动，对胎儿骨骼肌发育以及后代随后的代谢健康有着至关重要的影响。在这篇综述中，系统总结了母亲肥胖、营养不良和微量营养素摄入对胎儿骨骼肌发育的影响。我们还旨在描述母亲运动如何塑造胎儿肌肉发育以及后代的代谢健康。尽管这一领域仍处于“起步阶段”，但进一步讨论了母亲肠道微生物群及其代谢产物对胎儿肌肉发育的作用。这篇综述将为减少全球代谢紊乱危机提供新的见解，并突出当前的差距以促进进一步研究。
