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妊娠和哺乳期相关骨质疏松症（PLO）后经特立帕肽治疗的二胎病例报告

Second Child After Pregnancy and Lactation-Related Osteoporosis (PLO) Treated With Teriparatide: A Case Report.

作者信息

Yamada Shinsuke, Hayashi Noriyuki, Toi Norikazu, Miyaoka Daichi, Hashimoto Motomu

机构信息

Clinical Immunology, Osaka Metropolitan University of Medicine, Osaka, JPN.

Internal Medicine, Ohno Memorial Hospital, Osaka, JPN.

出版信息

Cureus. 2024 Jul 19;16(7):e64900. doi: 10.7759/cureus.64900. eCollection 2024 Jul.

DOI:10.7759/cureus.64900
PMID:39156353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11330588/
Abstract

Pregnancy and lactation-associated osteoporosis (PLO) is one of the rarest and most serious primary osteoporotic conditions that develops during the third trimester of gestation and/or early postpartum period. A history of PLO often causes individuals to hesitate when considering an additional child due to anxiety about recurrence risk. Reported here are details of a 29-year-old patient with PLO given aggressive treatment for osteoporosis with teriparatide who subsequently gave birth to a healthy child at age 33 without PLO recurrence. Further case studies are needed to examine the efficacy and safety of PLO treatment and to provide beneficial results for those who wish to have another pregnancy.

摘要

妊娠和哺乳期相关骨质疏松症（PLO）是最罕见、最严重的原发性骨质疏松症之一，发生在妊娠晚期和/或产后早期。PLO病史常常使患者在考虑再要一个孩子时犹豫不决，因为担心复发风险。本文报告了一名29岁PLO患者的详细情况，该患者接受了特立帕肽积极治疗骨质疏松症，随后在33岁时生下一个健康的孩子，且PLO未复发。需要进一步的病例研究来检验PLO治疗的有效性和安全性，并为那些希望再次怀孕的人提供有益的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0435/11330588/af94652a12c0/cureus-0016-00000064900-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0435/11330588/6dd1d87dbd62/cureus-0016-00000064900-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0435/11330588/4fe23a36d76b/cureus-0016-00000064900-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0435/11330588/af94652a12c0/cureus-0016-00000064900-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0435/11330588/6dd1d87dbd62/cureus-0016-00000064900-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0435/11330588/4fe23a36d76b/cureus-0016-00000064900-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0435/11330588/af94652a12c0/cureus-0016-00000064900-i03.jpg

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本文引用的文献

1
Pregnancy and Lactation-Associated Osteoporosis Successfully Treated with Romosozumab: A Case Report.妊娠和哺乳期相关骨质疏松症用罗莫佐单抗成功治疗：一例报告。
Medicina (Kaunas). 2022 Dec 22;59(1):19. doi: 10.3390/medicina59010019.
2
Analysis of Fracture Incidence in 135 Patients With Pregnancy and Lactation Osteoporosis (PLO).135例妊娠和哺乳期骨质疏松症（PLO）患者骨折发生率分析
Cureus. 2021 Oct 24;13(10):e19011. doi: 10.7759/cureus.19011. eCollection 2021 Oct.
3
Clinical characteristics and bisphosphonates treatment of rare pregnancy- and lactation-associated osteoporosis.
罕见的与妊娠和哺乳相关的骨质疏松症的临床特征和双磷酸盐治疗。
Clin Rheumatol. 2018 Nov;37(11):3141-3150. doi: 10.1007/s10067-018-4185-0. Epub 2018 Jun 26.
4
Subsequent fracture risk of women with pregnancy and lactation-associated osteoporosis after a median of 6 years of follow-up.妊娠和哺乳期相关骨质疏松症女性在中位 6 年随访后的后续骨折风险。
Osteoporos Int. 2018 Jan;29(1):135-142. doi: 10.1007/s00198-017-4239-1. Epub 2017 Sep 30.
5
Two cases of pregnancy- and lactation- associated osteoporosis successfully treated with denosumab.两例妊娠和哺乳期相关骨质疏松症患者经地诺单抗治疗成功。
Clin Cases Miner Bone Metab. 2016 Sep-Dec;13(3):244-246. doi: 10.11138/ccmbm/2016.13.3.244. Epub 2017 Feb 10.
6
Treatment with teriparatide in a patient with pregnancy-associated osteoporosis.特立帕肽治疗妊娠相关性骨质疏松症患者。
Gynecol Endocrinol. 2010 Oct;26(10):725-8. doi: 10.3109/09513591003649831.
7
Maternal and fetal outcome after long-term bisphosphonate exposure before conception.受孕前长期接触双膦酸盐后的母婴结局。
Osteoporos Int. 2010 Apr;21(4):709-10. doi: 10.1007/s00198-009-0983-1. Epub 2009 Jun 16.
8
A case report: pregnancy-induced severe osteoporosis with eight vertebral fractures.病例报告：妊娠诱发的严重骨质疏松症伴八处椎体骨折。
Rheumatol Int. 2008 Dec;29(2):197-201. doi: 10.1007/s00296-008-0641-5. Epub 2008 Jul 17.
9
Post-pregnancy osteoporosis; a syndrome?产后骨质疏松症；一种综合征？
Lancet. 1955 Feb 26;268(6861):431-4. doi: 10.1016/s0140-6736(55)90214-2.
10
The effects of pregnancy and lactation on hormonal status and biochemical markers of bone turnover.妊娠和哺乳期对激素状态及骨转换生化标志物的影响。
Eur J Obstet Gynecol Reprod Biol. 2003 Feb 10;106(2):209-13. doi: 10.1016/s0301-2115(02)00237-3.