复发性膀胱尿路上皮癌合并原发性膀胱大细胞神经内分泌癌：1例报告并文献复习
Recurrent bladder urothelial carcinoma complicated with primary bladder large cell neuroendocrine carcinoma: a case report and literature review.
作者信息
Cui Jiarui, Zhao Qing, Yu Chunhong, Ma Pengfei, Li Shoubin
机构信息
North China University of Science and Technology, Tangshan, Hebei, China.
Department of Urology, Hebei General Hospital, Shijiazhuang, Hebei, China.
出版信息
Front Oncol. 2024 Aug 2;14:1369649. doi: 10.3389/fonc.2024.1369649. eCollection 2024.
OBJECTIVE
To improve the understanding, diagnosis and treatment of bladder large cell neuroendocrine carcinoma (LCNEC).
METHODS
A clinical case of bladder LCNEC admitted to our hospital was reported. The epidemiology, prognosis, diagnosis and treatment methods of large cell neuroendocrine carcinoma were reviewed. The diagnosis and treatment status and prognosis were discussed based on the literature.
RESULTS
The female patient was admitted to hospital for "more than 4 years after TURBT and intermittent hematuria for more than 2 years". She was diagnosed as recurrent bladder cancer and underwent "radical cystotomy + hysterectomy". The postoperative pathological findings were high-grade urothelial carcinoma of the bladder neck and large cell neuroendocrine carcinoma of the bladder. The patient recovered well after surgery, but refused radiotherapy and chemotherapy and is still under close follow-up.
CONCLUSION
Bladder LCNEC is clinically rare, has unique pathological features, is more aggressive than traditional urothelial carcinoma, and has a poor prognosis. Surgery, chemotherapy and radiotherapy should be combined with multi-mode treatment.
目的
提高对膀胱大细胞神经内分泌癌（LCNEC）的认识、诊断及治疗水平。
方法
报道我院收治的1例膀胱LCNEC临床病例。回顾大细胞神经内分泌癌的流行病学、预后、诊断及治疗方法。结合文献讨论其诊断、治疗现状及预后。
结果
该女性患者因“TURBT术后4年余，间断血尿2年余”入院。诊断为复发性膀胱癌，行“根治性膀胱切除术+子宫切除术”。术后病理结果为膀胱颈高级别尿路上皮癌及膀胱大细胞神经内分泌癌。患者术后恢复良好，但拒绝放疗及化疗，仍在密切随访中。
结论
膀胱LCNEC临床罕见，具有独特的病理特征，比传统尿路上皮癌侵袭性更强，预后较差。应采用手术、化疗及放疗相结合的多模式治疗。
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