Yang Hefei, Wang Yuanrui, Wang Le-Cheng, Wu Xiao-Feng
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences 116023 Dalian Liaoning China
Leibniz-Institut für Katalyse e.V. 18059 Rostock Germany
Chem Sci. 2024 Aug 14;15(35):14304-9. doi: 10.1039/d4sc03221g.
Carbonylative transformation represents one of the most straightforward procedures for the synthesis of carbonyl-containing compounds. However, the carbonylative procedure toward 1,4-diketones is still limited which are key moieties with potent applications in various areas. Herein, we report a new strategy for the synthesis of multi-carbonyl compounds containing a 1,4-diketone skeleton through remote heteroaryl migration of traditionally restricted 1,3-migratory substrates utilizing carbon monoxide (CO) as the C1 synthon and diazonium compounds as the starting material.
羰基化转化是合成含羰基化合物最直接的方法之一。然而，针对1,4-二酮的羰基化反应仍然有限，而1,4-二酮是在各个领域具有重要应用的关键部分。在此，我们报道了一种合成含1,4-二酮骨架的多羰基化合物的新策略，该策略通过利用一氧化碳（CO）作为C1合成子，以重氮化合物为起始原料，使传统受限的1,3-迁移底物进行远程杂芳基迁移来实现。
