Hessels Arno C, Visser Sabine, Both Stefan, Korevaar Erik W, Langendijk Johannes A, Wijsman Robin
Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Phys Imaging Radiat Oncol. 2024 Jul 26;31:100616. doi: 10.1016/j.phro.2024.100616. eCollection 2024 Jul.
In non-small-cell lung cancer (NSCLC), improving local control through radiotherapy dose escalation might improve survival. However, a photon-based RCT showed increased organ at risk dose exposure and worse overall survival in the dose escalation arm. In this study, intensity-modulated proton therapy plans with dose escalation to the primary tumour were created for 20 NSCLC patients. The mediastinal envelope was delineated to spare structures around the heart. It was possible to increase primary tumour dose up to 74.0 Gy without a significant increase in organ at risk doses and predicted toxicity.
在非小细胞肺癌（NSCLC）中，通过增加放疗剂量来改善局部控制可能会提高生存率。然而，一项基于光子的随机对照试验显示，剂量增加组的危及器官剂量暴露增加，总生存率更差。在本研究中，为20例NSCLC患者制定了对原发肿瘤进行剂量增加的调强质子治疗计划。勾画纵隔包膜以保护心脏周围结构。在不显著增加危及器官剂量和预测毒性的情况下，有可能将原发肿瘤剂量增加至74.0 Gy。
