Top Alexander C R, Vanmierlo Bert, Decramer Arne
Department of Orthopaedics, AZ Delta, Roeselare, Belgium.
J Orthop Case Rep. 2024 Aug;14(8):6-9. doi: 10.13107/jocr.2024.v14.i08.4626.
Avascular necrosis of the lunate bone has been extensively researched, although the etiology of the condition remains controversial. Even though many treatments for the disease exist, a better understanding of the pathophysiology can improve our decision-making between preventive and therapeutic measures. Various hematological disorders have been found to predispose for Kienböck's disease. On the other hand, there has not yet been any reference in literature to a relationship between this condition and hereditary hemochromatosis (HH).
We present two cases of Kienböck's disease in two patients who are third-degree relatives and diagnosed with HH. A 61-year-old Caucasian female patient with type 1 HH presented with symptomatic Kienböck's disease on the left side. The patient is a third-degree relative of a 51-year-old male Caucasian patient with Kienbock's disease on the right side, known as having the same hereditary hematological condition.
Our findings suggest a potential correlation between the aforementioned conditions. The prevalence of these coexisting pathologies should be studied further.
尽管月骨缺血性坏死的病因仍存在争议,但对此病症已进行了广泛研究。虽然针对该疾病有多种治疗方法,但更好地了解其病理生理学有助于我们在预防和治疗措施之间做出更明智的决策。已发现多种血液系统疾病易引发月骨无菌性坏死。另一方面,文献中尚未提及这种病症与遗传性血色素沉着症(HH)之间的关系。
我们报告两例月骨无菌性坏死病例,两名患者为三级亲属,均被诊断为遗传性血色素沉着症。一名61岁的1型遗传性血色素沉着症白种女性患者左侧出现有症状的月骨无菌性坏死。该患者是一名51岁右侧患有月骨无菌性坏死的白种男性患者的三级亲属,已知后者患有相同的遗传性血液疾病。
我们的研究结果表明上述病症之间可能存在关联。这些共存病症的患病率应进一步研究。