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双重打击:一例同时存在酒精使用与遗传性血色素沉着症导致股骨缺血性坏死的病例

Double Whammy: A Case of Concurrent Alcohol Use and Hereditary Hemochromatosis Leading to Avascular Necrosis of the Femur.

作者信息

Albers Christine E, Albers Janet, Sapra Amit, Bhandari Priyanka, Ranjit Eukesh

机构信息

Family and Community Medicine, Southern Illinois University School of Medicine, Springfield, USA.

Family Medicine, Southern Illinois University School of Medicine, Springfield, USA.

出版信息

Cureus. 2021 Sep 17;13(9):e18067. doi: 10.7759/cureus.18067. eCollection 2021 Sep.

DOI:10.7759/cureus.18067
PMID:34692289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8523389/
Abstract

Avascular necrosis (AVN) of the femur is due to damage to the vasculature of the bone and can include a multitude of causes including medications, alcohol intake, hemoglobinopathies, thrombophilias, and connective tissue disorders, among others. Hereditary hemochromatosis is not a common cause of AVN but should be considered prior to labeling such cases as idiopathic. If a patient has symptoms of persistent hip pain and plain radiography has been unremarkable, one should proceed with magnetic resonance imaging (MRI) of the affected joint due to its sensitivity in detecting osteonecrosis. We present a case report of a 54-year-old male patient with a significant history of alcohol intake and a diagnosis of hereditary hemochromatosis who presented with persistent left hip pain and further imaging revealed the presence of osteonecrosis of the femur.

摘要

股骨缺血性坏死(AVN)是由于骨血管受损所致,其病因众多,包括药物、酒精摄入、血红蛋白病、血栓形成倾向以及结缔组织疾病等。遗传性血色素沉着症并非AVN的常见病因,但在将此类病例标记为特发性之前应予以考虑。如果患者有持续性髋关节疼痛症状且X线平片无明显异常,由于磁共振成像(MRI)对检测骨坏死具有敏感性,应进行患侧关节的MRI检查。我们报告一例54岁男性患者,有大量饮酒史且诊断为遗传性血色素沉着症,该患者出现持续性左髋疼痛,进一步影像学检查显示存在股骨骨坏死。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/8523389/ec8116b474ac/cureus-0013-00000018067-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/8523389/24910ff11fc6/cureus-0013-00000018067-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/8523389/1cba43255515/cureus-0013-00000018067-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/8523389/ec8116b474ac/cureus-0013-00000018067-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/8523389/24910ff11fc6/cureus-0013-00000018067-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/8523389/1cba43255515/cureus-0013-00000018067-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/8523389/ec8116b474ac/cureus-0013-00000018067-i03.jpg

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J Orthop Case Rep. 2024 Aug;14(8):6-9. doi: 10.13107/jocr.2024.v14.i08.4626.

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