个性化路径：通过肠脑轴攻克阿尔茨海默病
Personalized Paths: Unlocking Alzheimer's via the Gut-Brain Axis.
作者信息
Ceccon Matteo, Kantsjö Johan B, Ronchi Francesca
机构信息
Institute of Microbiology, Infectious Disease, and Immunology/Charité - Universitätsmedizin Berlin, Berlin, Germany.
出版信息
Visc Med. 2024 Aug;40(4):194-209. doi: 10.1159/000535869. Epub 2024 Apr 8.
BACKGROUND
Alzheimer's disease (AD) is characterised by abnormal protein aggregates in the brain that lead to cognitive decline. While current therapies only treat symptoms, disease-modifying treatments are urgently needed. Studies suggest that the composition of the microbiota is altered in people with AD, suggesting a link between gut bacteria and AD-related brain changes.
SUMMARY
In our narrative review, we explore various microbial interventions, such as faecal microbiota transplantation, probiotics, and diet, as powerful potential treatments. Studies suggest changes in microbiota composition following these interventions, with some beneficial effects on cognitive function. However, the mechanism of action of these microbial interventions is still unknown.
KEY MESSAGE
Our aim was to highlight the importance of personalised approaches, taking into account individual metabolic and microbiome profiles. We try to address gaps in current research and emphasise the need for microbiota analysis at different stages of the disease and its integration with clinical parameters and lifestyle information for a comprehensive understanding of AD progression (summarised in online suppl. Fig. 1; for all online suppl. material, see https://doi.org/10.1159/000535869).
背景
阿尔茨海默病（AD）的特征是大脑中异常蛋白质聚集，导致认知能力下降。虽然目前的疗法仅能治疗症状，但迫切需要改变疾病进程的治疗方法。研究表明，AD患者的微生物群组成发生了改变，这表明肠道细菌与AD相关的大脑变化之间存在联系。
总结
在我们的叙述性综述中，我们探讨了各种微生物干预措施，如粪便微生物群移植、益生菌和饮食，它们是很有潜力的治疗方法。研究表明，这些干预措施会导致微生物群组成发生变化，对认知功能有一些有益影响。然而，这些微生物干预措施的作用机制仍然未知。
关键信息
我们的目的是强调个性化方法的重要性，要考虑个体的代谢和微生物组概况。我们试图填补当前研究的空白，并强调在疾病的不同阶段进行微生物群分析的必要性，以及将其与临床参数和生活方式信息相结合，以全面了解AD的进展（总结于在线补充图1；所有在线补充材料见https://doi.org/10.1159/000535869）。
Zotero 插件