College of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia, People's Republic of China.
College of Pharmacy, Baotou Medical College, Baotou, People's Republic of China.
Int J Nanomedicine. 2024 Aug 12;19:8175-8188. doi: 10.2147/IJN.S472038. eCollection 2024.
Exosomes belong to a subgroup of extracellular vesicles secreted by various cells and are involved in intercellular communication and material transfer. In recent years, exosomes have been used as drug delivery carriers because of their natural origin, high stability, low immunogenicity and high engineering ability. However, achieving targeted drug delivery with exosomes remains challenging. In this paper, a phage display technology was used to screen targeted peptides, and different surface modification strategies of targeted peptide exosomes were reviewed. In addition, the application of peptide-targeted exosomes in pulmonary diseases was also summarised.
外泌体属于由各种细胞分泌的细胞外囊泡的一个亚群，参与细胞间的通讯和物质传递。近年来，外泌体由于其天然来源、高稳定性、低免疫原性和高工程能力，被用作药物递送载体。然而，利用外泌体实现靶向药物递送仍然具有挑战性。本文利用噬菌体展示技术筛选靶向肽，并综述了靶向肽外泌体的不同表面修饰策略。此外，还总结了肽靶向外泌体在肺部疾病中的应用。
