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NUP98 is rearranged in 5.0% of adult East Asian patients with AML.

作者信息

Kim Namsoo, Choi Yu Jeong, Cho Hyunsoo, Jang Ji Eun, Lee Seung-Tae, Song Jaewoo, Choi Jong Rak, Cheong June-Won, Chung Haerim, Shin Saeam

机构信息

Department of Laboratory Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.

Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.

出版信息

Blood Adv. 2024 Oct 8;8(19):5122-5125. doi: 10.1182/bloodadvances.2024012960.

DOI:10.1182/bloodadvances.2024012960
PMID:39158088
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11460442/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/946d/11460442/bf5458f5b816/BLOODA_ADV-2024-012960-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/946d/11460442/bf5458f5b816/BLOODA_ADV-2024-012960-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/946d/11460442/bf5458f5b816/BLOODA_ADV-2024-012960-gr1.jpg

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NUP98 is rearranged in 5.0% of adult East Asian patients with AML.在5.0%的成年东亚急性髓系白血病患者中，核孔蛋白98（NUP98）发生重排。
Blood Adv. 2024 Oct 8;8(19):5122-5125. doi: 10.1182/bloodadvances.2024012960.
2
Adult acute myeloid leukemia patients with rearrangement have frequent cryptic translocations and unfavorable outcome.成人急性髓系白血病伴重现性遗传学异常患者常有隐匿性易位且预后不良。
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3
[Clinical Characteristics and Prognosis of Adult Acute Myeloid Leukemia with NUP98 Gene Rearrangement].[伴有NUP98基因重排的成人急性髓系白血病的临床特征与预后]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Oct;29(5):1450-1455. doi: 10.19746/j.cnki.issn.1009-2137.2021.05.012.
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The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.Menin-MLL1 相互作用是 NUP98 重排 AML 中的一个分子依赖性。
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NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern.NUP98/NSD1 特征为急性髓系白血病中具有独特 HOX 基因表达模式的新型预后不良组。
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NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis.NUP98 基因重排在 3.8% 的儿童急性髓系白血病中发生，形成了一个具有临床和分子均一性、预后不良的群组。
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First case report of a NUP98-PMX1 rearrangement in de novo acute myeloid leukemia and literature review.首例 NUP98-PMX1 重排的初发急性髓系白血病病例报告及文献复习。
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Targeted gene sequencing and transcriptome sequencing reveal characteristics of NUP98 rearrangement in pediatric acute myeloid leukemia.靶向基因测序和转录组测序揭示儿童急性髓系白血病中 NUP98 重排的特征。
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The landscape of NUP98 rearrangements clinical characteristics and treatment response from 1491 acute leukemia patients.1491例急性白血病患者的NUP98重排的临床特征及治疗反应情况
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NUP-98 Rearrangements Led to the Identification of Candidate Biomarkers for Primary Induction Failure in Pediatric Acute Myeloid Leukemia.NUP98 重排导致了儿科急性髓系白血病原代诱导失败的候选生物标志物的鉴定。
Int J Mol Sci. 2021 Apr 27;22(9):4575. doi: 10.3390/ijms22094575.

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本文引用的文献

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Combination of menin and kinase inhibitors as an effective treatment for leukemia with NUP98 translocations.联合使用 menin 和激酶抑制剂治疗 NUP98 易位白血病的有效方法。
Leukemia. 2024 Aug;38(8):1674-1687. doi: 10.1038/s41375-024-02312-9. Epub 2024 Jun 18.
2
CEBPA double mutations associated with ABO antigen weakness in hematologic diseases.CEBPA 双突变与血液系统疾病中的 ABO 抗原减弱相关。
Blood Adv. 2024 Mar 26;8(6):1487-1493. doi: 10.1182/bloodadvances.2023011572.
3
Allogeneic stem cell transplantation can prolong the survival of patients with NUP98-rearranged acute myeloid leukemia.
异基因干细胞移植可延长NUP98重排的急性髓系白血病患者的生存期。
Bone Marrow Transplant. 2023 Oct;58(10):1149-1151. doi: 10.1038/s41409-023-02030-3. Epub 2023 Jul 7.
4
Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia.基于转录组的分子亚型和分化层次提高了急性髓系白血病的分类框架。
Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2211429119. doi: 10.1073/pnas.2211429119. Epub 2022 Nov 28.
5
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data.国际髓系肿瘤和急性白血病分类：整合形态学、临床和基因组数据。
Blood. 2022 Sep 15;140(11):1200-1228. doi: 10.1182/blood.2022015850.
6
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.世界卫生组织血液淋巴肿瘤分类第五版：髓系和组织细胞/树突状肿瘤。
Leukemia. 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. Epub 2022 Jun 22.
7
Adult acute myeloid leukemia patients with rearrangement have frequent cryptic translocations and unfavorable outcome.成人急性髓系白血病伴重现性遗传学异常患者常有隐匿性易位且预后不良。
Leuk Lymphoma. 2022 Aug;63(8):1907-1916. doi: 10.1080/10428194.2022.2047672. Epub 2022 Mar 8.
8
A comparative study of next-generation sequencing and fragment analysis for the detection and allelic ratio determination of FLT3 internal tandem duplication.用于检测和等位基因比测定的 FLT3 内部串联重复的下一代测序与片段分析的比较研究。
Diagn Pathol. 2022 Jan 26;17(1):14. doi: 10.1186/s13000-022-01202-x.
9
The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.Menin-MLL1 相互作用是 NUP98 重排 AML 中的一个分子依赖性。
Blood. 2022 Feb 10;139(6):894-906. doi: 10.1182/blood.2021012806.
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Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies.NUP98 重排血液系统恶性肿瘤的机制见解和潜在治疗方法。
Blood. 2020 Nov 12;136(20):2275-2289. doi: 10.1182/blood.2020007093.