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Emergence of clonal evolution with Philadelphia chromosome in acute myeloid leukemia after hypomethylation agents and BCL2 inhibitor treatment.甲基化抑制剂和BCL2抑制剂治疗后急性髓系白血病中伴费城染色体的克隆进化的出现
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Complete cytogenetic remission after decitabine treatment in a patient with secondary AML harbouring high p15INK4b gene methylation and high global DNA methylation.一名患有继发性急性髓系白血病(AML)且伴有高p15INK4b基因甲基化和高整体DNA甲基化的患者在接受地西他滨治疗后实现了细胞遗传学完全缓解。
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本文引用的文献

1
Comprehensive molecular characterization of a rare case of Philadelphia chromosome-positive acute myeloid leukemia.对一例罕见的费城染色体阳性急性髓细胞白血病进行全面分子特征分析。
Cold Spring Harb Mol Case Stud. 2022 Oct 28;8(6). doi: 10.1101/mcs.a006218. Print 2022 Oct.
2
Emergence of - Fusion in AML Post-FLT3 Inhibitor-Based Therapy: A Potentially Targetable Mechanism of Resistance - A Case Series.基于FLT3抑制剂治疗的急性髓系白血病中-融合的出现:一种潜在的可靶向耐药机制——病例系列
Front Oncol. 2020 Oct 20;10:588876. doi: 10.3389/fonc.2020.588876. eCollection 2020.
3
Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome.治疗急性白血病和骨髓增生异常综合征期间获得的继发性费城染色体。
Mod Pathol. 2018 Jul;31(7):1141-1154. doi: 10.1038/s41379-018-0014-x. Epub 2018 Feb 14.
4
Philadelphia chromosome-positive acute myeloid leukemia: a rare aggressive leukemia with clinicopathologic features distinct from chronic myeloid leukemia in myeloid blast crisis.费城染色体阳性急性髓系白血病:一种罕见的侵袭性白血病,其临床病理特征与慢性髓系白血病急变期不同。
Am J Clin Pathol. 2007 Apr;127(4):642-50. doi: 10.1309/B4NVER1AJJ84CTUU.
5
Philadelphia chromosome positive myelodysplastic syndrome and acute myeloid leukemia-retrospective study and review of literature.费城染色体阳性骨髓增生异常综合征和急性髓系白血病——回顾性研究及文献综述
Leuk Res. 2004 Jun;28(6):579-86. doi: 10.1016/j.leukres.2003.10.027.

Emergence of clonal evolution with Philadelphia chromosome in acute myeloid leukemia after hypomethylation agents and BCL2 inhibitor treatment.

作者信息

Kao Shih-Yu, Hsiao Samuel Y, Du Bi-Hua, Hsiao Hui-Hua

机构信息

Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

出版信息

Kaohsiung J Med Sci. 2024 Oct;40(10):947-948. doi: 10.1002/kjm2.12886. Epub 2024 Aug 19.

DOI:10.1002/kjm2.12886
PMID:39158166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11895594/
Abstract
摘要