Li Jinquan, Zhang Shanzhong, Hu Xiaosheng, Huang Tao, Chen Mingmin
Department of Gastrointestinal Surgery, The First People's Hospital of Jingdezhen, No. 317 Zhonghuabei Road, Zhushan District, Jingdezhen, 33300, Jiangxi, China.
Surg Today. 2025 Apr;55(4):483-491. doi: 10.1007/s00595-024-02921-y. Epub 2024 Aug 19.
The C-Reactive Protein (CRP)-Albumin-Lymphocyte (CALLY) index is an established immuno-nutritional scoring system. We screened relevant literature from the major databases up until May, 2024, and extracted the data for analysis. A total of 2829 gastric cancer (GC) patients from six studies were included in this meta-analysis, the results of which revealed that the CALLY index was an independent prognostic factor for OS and RFS in both univariate analyses and multivariate analyses, and that a high CALLY index was a favorable prognostic factor. Moreover, GC patients in the high CALLY index group seemed to have better 5-year OS and 5-year RFS than those in the low CALLY index group. There was a higher proportion of patients with T1 status in the high CALLY index group than in the low CALLY index group. However, the opposite results were found in the analyses of lymph node metastasis positivity, lymph-vascular invasion positivity, postoperative complications, differentiated histological type, anastomotic leakage, and adjuvant chemotherapy. The present meta-analysis concluded that the CALLY index was a simple and useful independent prognostic biomarker for GC patients after gastrectomy.
C反应蛋白（CRP）-白蛋白-淋巴细胞（CALLY）指数是一种既定的免疫营养评分系统。我们检索了截至2024年5月主要数据库中的相关文献，并提取数据进行分析。本荟萃分析纳入了六项研究中的2829例胃癌（GC）患者，结果显示，在单因素分析和多因素分析中，CALLY指数都是总生存期（OS）和无复发生存期（RFS）的独立预后因素，且CALLY指数高是一个有利的预后因素。此外，高CALLY指数组的GC患者似乎比低CALLY指数组的患者有更好的5年总生存率和5年无复发生存率。高CALLY指数组中T1期患者的比例高于低CALLY指数组。然而，在淋巴结转移阳性、淋巴管侵犯阳性、术后并发症、组织学分化类型、吻合口漏和辅助化疗的分析中发现了相反的结果。本荟萃分析得出结论，CALLY指数是胃癌患者胃切除术后一个简单且有用的独立预后生物标志物。
