采用99mTc-DTPAγ相机技术测量单肾肾小球滤过率的可靠性。

Reliability of single kidney glomerular filtration rate measured by a 99mTc-DTPA gamma camera technique.

作者信息

Rehling M, Møller M L, Jensen J J, Thamdrup B, Lund J O, Trap-Jensen J

出版信息

Uremia Invest. 1985;9(2):171-6. doi: 10.3109/08860228509088207.

Abstract

The reliability of a previously published method for determination of single kidney glomerular filtration rate (SKGFR) by means of technetium-99m-diethylenetriaminepenta-acetate (99mTc-DTPA) gamma camera renography was evaluated. The day-to-day variation in the calculated SKGFR values was earlier found to be 8.8%. The technique was compared to the simultaneously measured renal clearance of inulin in 19 unilaterally nephrectomized patients with GFR varying from 11 to 76 ml/min. The regression line (y = 1.04 X -2.5) did not differ significantly from the line of identity. The standard error of estimate was 4.3 ml/min. In 17 patients the inter- and intraobserver variation of the calculated SKGFR values was 1.2 ml/min and 1.3 ml/min, respectively. In 21 of 25 healthy subjects studied (age range 27-29 years), total GFR calculated from the renograms was within an established age-dependent normal range of GFR.

摘要

我们评估了一种先前发表的通过锝-99m-二乙三胺五乙酸（99mTc-DTPA）γ相机肾图测定单肾肾小球滤过率（SKGFR）方法的可靠性。先前发现计算得出的SKGFR值的每日变化为8.8%。该技术与19例单侧肾切除患者同时测量的菊粉肾清除率进行了比较，这些患者的肾小球滤过率（GFR）在11至76 ml/分钟之间。回归线（y = 1.04X - 2.5）与恒等线无显著差异。估计标准误差为4.3 ml/分钟。在17例患者中，计算得出的SKGFR值的观察者间和观察者内变异分别为1.2 ml/分钟和1.3 ml/分钟。在研究的25名健康受试者（年龄范围27 - 29岁）中的21名中，根据肾图计算得出的总GFR在既定的年龄依赖性GFR正常范围内。