血管紧张素转换酶抑制剂治疗后肾脏闪烁扫描在肾血管性高血压诊断中的应用

Kidney scintigraphy after ACE inhibition in the diagnosis of renovascular hypertension.

作者信息

Ghione S, Fommei E, Palombo C, Giaconi S, Mantovanelli A, Ragazzini A, Palla L

出版信息

Uremia Invest. 1985;9(2):211-5. doi: 10.3109/08860228509088213.

Abstract

Suppression of the renin-angiotensin system (RAS) by angiotensin converting enzyme (ACE) inhibition may induce renal failure in patients with bilateral renal artery stenosis. Recent scintigraphic studies with the glomerular tracer technetium-99m-diethylenetriaminepenta-acetate (99m-Tc DTPA) indicate that in patients with unilateral renal artery stenosis, glomerular filtration rate (GFR) may be markedly reduced in the affected kidney after inhibition of ACE. This finding reflects the important role of the RAS in maintaining GFR (by increasing postglomerular resistance) in states of low renal perfusion pressure. Preliminary observations suggest that this scintigraphic test might be useful in the detection of renovascular hypertension.

摘要

通过抑制血管紧张素转换酶（ACE）来抑制肾素-血管紧张素系统（RAS）可能会导致双侧肾动脉狭窄患者出现肾衰竭。最近使用肾小球示踪剂锝-99m-二乙三胺五乙酸（99m-Tc DTPA）进行的闪烁扫描研究表明，在单侧肾动脉狭窄患者中，抑制ACE后，患侧肾脏的肾小球滤过率（GFR）可能会显著降低。这一发现反映了RAS在肾灌注压低的状态下（通过增加肾小球后阻力）维持GFR的重要作用。初步观察表明，这种闪烁扫描试验可能有助于检测肾血管性高血压。