Zhang Jing, Shi Mengyao, Zhang Qilu, Chen Yi, Yin Xiangyan, Wang Xiaoxiao, Zhang Yonghong
Department of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China,
Department of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Neuroepidemiology. 2025;59(4):381-390. doi: 10.1159/000540955. Epub 2024 Aug 19.
Constipation is common in patients with Parkinson's disease (PD), but its impact on incident PD remains uncertain. We aimed to prospectively investigate constipation symptoms and the risk of PD.
Participants without PD at baseline from the UK Biobank were included in the study. Information on the regular use of laxatives, bowel movement frequency, and the frequency of hard or lumpy stools was collected. Incident PD was defined by the ICD-10 code. Cox proportional hazards models were used to assess the association between constipation symptoms and incident PD.
In the analysis of regular laxative use and PD, 490,797 participants were included and 2,735 incident PD were detected. The multivariable adjusted HR of PD in participants who regularly used laxatives was 1.99 (95% confidence interval [CI], 1.70-2.33) compared with those who did not. In the analysis of bowel movement frequency and hard or lumpy stools and PD, 170,017 participants were included and 519 incident PD were detected. The multivariable adjusted HRs were 2.16 (95% CI, 1.74-2.68) and 2.57 (95% CI, 2.00-3.31) for participants with a bowel movement frequency of 3-6 times/week and <3 times/week, respectively, compared with those with a bowel movement frequency of ≥7 times/week; compared with participants who never had hard or lumpy stools, multivariable adjusted HRs were 1.31 (95% CI, 1.07-1.60), 2.32 (95% CI, 1.77-3.05), and 2.94 (95% CI, 2.14-4.05) for those who sometimes had hard or lumpy stools, often had hard or lumpy stools, and most of time/always had hard or lumpy stools, respectively.
Constipation measured by the regular use of laxatives, bowel movement frequency, and the frequency of hard or lumpy stools was significantly associated with an increased risk of incident PD.
便秘在帕金森病（PD）患者中很常见，但其对帕金森病发病的影响仍不确定。我们旨在前瞻性地研究便秘症状与帕金森病风险之间的关系。
纳入英国生物银行中基线时无帕金森病的参与者。收集有关泻药的常规使用情况、排便频率以及硬便或块状便频率的信息。帕金森病的发病由国际疾病分类第10版（ICD - 10）编码定义。采用Cox比例风险模型评估便秘症状与帕金森病发病之间的关联。
在对泻药常规使用情况与帕金森病的分析中，纳入了490,797名参与者，检测到2,735例帕金森病发病病例。与未经常使用泻药的参与者相比，经常使用泻药的参与者发生帕金森病的多变量调整风险比（HR）为1.99（95%置信区间[CI]，1.70 - 2.33）。在对排便频率、硬便或块状便与帕金森病的分析中，纳入了170,017名参与者，检测到519例帕金森病发病病例。与排便频率≥7次/周的参与者相比，排便频率为3 - 6次/周和<3次/周的参与者发生帕金森病的多变量调整HR分别为2.16（95%CI，1.74 - 2.68）和2.57（95%CI，2.00 - 3.31）；与从未有过硬便或块状便的参与者相比，有时有、经常有以及大部分时间/总是有硬便或块状便的参与者发生帕金森病的多变量调整HR分别为1.31（95%CI，1.07 - 1.60）、2.32（95%CI，1.77 - 3.05）和2.94（95%CI，2.14 - 4.05）。
通过泻药的常规使用、排便频率以及硬便或块状便频率衡量的便秘与帕金森病发病风险增加显著相关。
