Neuropsychology and Functional Neuroimaging, Universitat Jaume I, Castelllón de la Plana 12071, Spain.
Department of Psychology, University of York, York YO10 5DD, United Kingdom.
J Neurosci. 2024 Sep 11;44(37):e2430232024. doi: 10.1523/JNEUROSCI.2430-23.2024.
During infancy and adolescence, language develops from a predominantly interhemispheric control-through the corpus callosum (CC)-to a predominantly intrahemispheric control, mainly subserved by the left arcuate fasciculus (AF). Using multimodal neuroimaging, we demonstrate that human left-handers (both male and female) with an atypical language lateralization show a rightward participation of language areas from the auditory cortex to the inferior frontal cortex when contrasting speech to tone perception and an enhanced interhemispheric anatomical and functional connectivity. Crucially, musicianship determines two different structural pathways to this outcome. Nonmusicians present a relation between atypical lateralization and intrahemispheric underdevelopment across the anterior AF, hinting at a dysregulation of the ontogenetic shift from an interhemispheric to an intrahemispheric brain. Musicians reveal an alternative pathway related to interhemispheric overdevelopment across the posterior CC and the auditory cortex. We discuss the heterogeneity in reaching atypical language lateralization and the relevance of early musical training in altering the normal development of language cognitive functions.
在婴儿期和青春期，语言的发展从主要通过胼胝体（CC）的半球间控制转变为主要由左弓状束（AF）支持的半球内控制。使用多模态神经影像学，我们证明了具有非典型语言侧化的人类左撇子（男性和女性）在将言语与音高感知进行对比时，语言区域从听觉皮层到下额前皮层呈现出右侧参与，并且大脑左右半球之间的解剖和功能连接增强。至关重要的是，音乐才能决定了达到这一结果的两种不同的结构途径。非音乐家表现出非典型侧化与前弓状束内发育不足之间的关系，暗示了从半球间到半球内大脑的发育转变的失调。音乐家则揭示了与后部 CC 和听觉皮层的半球间过度发育相关的另一种途径。我们讨论了达到非典型语言侧化的异质性，以及早期音乐训练在改变语言认知功能的正常发育方面的重要性。
