Belisario A, Panza N, Pacilio G
Acta Vitaminol Enzymol. 1985;7 Suppl:75-8.
Mutagenic activity on Salmonella typhimurium strains of some cytostatic drugs in the absence and in the presence of beta-carotene was evaluated. Cyclophosphamide mutagenicity was reduced by the retinoid both in vitro and in vivo. Conversely, its metabolite 4'-hydroxy-cyclophosphamide, which does not require enzymatic transformation to exert genotoxic activity against bacteria, was not affected by the presence of beta-carotene. Moreover, the mutagenic activity of cis-Platinum, Adriamycin and 4'Epiadriamycin, which are typical direct-acting mutagens, was not affected by beta-carotene. Data obtained confirm that beta-carotene is able to prevent mutagenic activity of cyclophosphamide by interfering with its metabolic activation but failed to inhibit the interaction of genotoxic compounds with bacterial DNA.
评估了某些细胞抑制药物在不存在和存在β-胡萝卜素的情况下对鼠伤寒沙门氏菌菌株的致突变活性。在体外和体内，类视黄醇均降低了环磷酰胺的致突变性。相反，其代谢物4'-羟基环磷酰胺（对细菌发挥基因毒性活性不需要酶促转化）不受β-胡萝卜素存在的影响。此外，顺铂、阿霉素和4'-表阿霉素（典型的直接作用诱变剂）的致突变活性也不受β-胡萝卜素的影响。获得的数据证实，β-胡萝卜素能够通过干扰环磷酰胺的代谢活化来预防其致突变活性，但未能抑制基因毒性化合物与细菌DNA的相互作用。
