Key Laboratory of Digestive Diseases, Lanzhou University Second Hospital, Lanzhou, 730030, China.
The Second Clinical Medical College, Lanzhou University, Lanzhou, 730030, China.
Cell Commun Signal. 2024 Aug 19;22(1):404. doi: 10.1186/s12964-024-01786-5.
SUMOylation, a post-translational modification involving the covalent attachment of small ubiquitin-like modifier (SUMO) proteins to target substrates, plays a pivotal role at the intersection of gut health and disease, influencing various aspects of intestinal physiology and pathology. This review provides a comprehensive examination of SUMOylation's diverse roles within the gut microenvironment. We examine its critical roles in maintaining epithelial barrier integrity, regulating immune responses, and mediating host-microbe interactions, thereby highlighting the complex molecular mechanisms that underpin gut homeostasis. Furthermore, we explore the impact of SUMOylation dysregulation in various intestinal disorders, including inflammatory bowel diseases and colorectal cancer, highlighting its implications as a potential diagnostic biomarker and therapeutic target. By integrating current research findings, this review offers valuable insights into the dynamic interplay between SUMOylation and gut health, paving the way for novel therapeutic strategies aimed at restoring intestinal equilibrium and combating associated pathologies.
SUMOylation，一种涉及将小泛素样修饰物（SUMO）蛋白共价连接到靶底物的翻译后修饰，在肠道健康和疾病的交汇点发挥着关键作用，影响着肠道生理学和病理学的各个方面。本综述全面考察了 SUMOylation 在肠道微环境中的多种作用。我们研究了它在维持上皮屏障完整性、调节免疫反应以及介导宿主-微生物相互作用方面的关键作用，从而突出了维持肠道内稳态的复杂分子机制。此外，我们还探讨了 SUMOylation 失调在各种肠道疾病（包括炎症性肠病和结直肠癌）中的影响，强调了其作为潜在诊断生物标志物和治疗靶点的意义。通过整合当前的研究结果，本综述为 SUMOylation 与肠道健康之间的动态相互作用提供了有价值的见解，为旨在恢复肠道平衡和治疗相关疾病的新型治疗策略铺平了道路。
