可见光激活的高效钙螯合作用。
Highly efficient Ca chelation activated by visible light.
作者信息
Egodawaththa Nishal M, Rajhel Olivia, Ma Jingxuan, Guruge Charitha, Pabarue Alec B, Harris Emily, Peverati Roberto, Nesnas Nasri
机构信息
Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA.
出版信息
Org Biomol Chem. 2024 Sep 11;22(35):7194-7202. doi: 10.1039/d4ob00951g.
Abstract
Calcium ion (Ca) control is an essential tool in neuronal research. Herein, we report three thiocoumarin-based, visible light-activated Ca chelators with quantum yields of 0.39, 0.52, and 0.83. The chelators demonstrated an over 10-fold increase in Ca binding affinity upon irradiation. These chelators are efficiently triggered by biologically safer wavelengths, rendering them excellent candidates for use in neurological research and medicine.
摘要
钙离子（Ca）控制是神经元研究中的一项重要工具。在此，我们报告了三种基于硫代香豆素的可见光激活钙螯合剂，其量子产率分别为0.39、0.52和0.83。这些螯合剂在光照后表现出超过10倍的钙结合亲和力增加。这些螯合剂能被生物安全性更高的波长有效触发，使其成为神经学研究和医学应用的优秀候选者。
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