Department of Gynecology and Obstetrics, Maternity and Child Healthcare Hospital Affiliated to Anhui Medical University, Anhui Province Maternity and Child Healthcare Hospital, Hefei, Anhui 230001, China.
Department of Gynecology and Obstetrics, The Fifth Clinical College of Anhui Medical University, Hefei, Anhui 230032, China.
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241277699. doi: 10.1177/15330338241277699.
A strong association was previously established between body mass index (BMI) and female reproductive system tumors; however, the causal relationship is unclear. We conducted a Mendelian randomization (MR) study to further explore this association. Genetic information for BMI was retrieved from a published genome-wide association study involving 339,224 participants. Genetic associations with five common female reproductive system tumors were obtained from the FinnGen, UK Biobank studies, and other large consortia. Genetic predisposition towards BMI exhibits a significant association with multiple tumors of the female reproductive system. Specifically, for every 1-unit increase in BMI log-transformed odds ratio (OR). The OR fluctuations overall for patients with breast cancer ranged from 0.661 to 0.996 (95% confidence interval [CI],0.544-1.000, P < 0.05). When stratified by estrogen receptor (ER) status, the OR for patients with ER (+) breast cancer ranged from 0.782 to 0.844 (95% CI, 0.616-0.994, P < 0.05) and that for those with ER (-) breast cancer ranged from 0.663 to 0.789 (95% CI, 0.498-0.991, P < 0.05). Additionally, ORs were as follows for cancer types: 1.577-1.908 (95% CI, 1.049-2.371, P < 0.05) for endometrial carcinoma; 1.216-1.303 (95% CI, 1.021-1.591, P < 0.05) for high-grade serous ovarian cancer; 1.217 (95% CI, 1.034-1.432, P < 0.05) for low-grade malignant serous ovarian cancer; and 1.502 (95% CI, 1.112-2.029, P < 0.05) for endometrioid ovarian carcinoma. Furthermore, our findings indicated that genetic predisposition towards BMI did not exhibit a causal association with uterine fibroids, cervical precancerous lesions, or cervical cancer itself. A genetic association was established between a high BMI and high risk of developing multiple tumors of the female reproductive system and their associated subtypes. This underscores the significance of taking measures to prevent reproductive system tumors in women who have a high BMI.
遗传易感性与多种女性生殖系统肿瘤显著相关。
一种强关联性先前已被确立，即体重指数（BMI）与女性生殖系统肿瘤之间存在关联；然而，其因果关系尚不清楚。我们进行了一项孟德尔随机化（MR）研究，以进一步探究这种关联性。BMI 的遗传信息源自一项涉及 339224 名参与者的已发表全基因组关联研究。五种常见女性生殖系统肿瘤的遗传关联则来自 FinnGen、英国生物库研究以及其他大型联盟的研究。
遗传易感性与多种女性生殖系统肿瘤显著相关。具体而言，对于 BMI 的每单位增加，经对数转换后的比值比（OR）的波动范围为 0.661 至 0.996（95%置信区间[CI]，0.544-1.000，P<0.05）。按雌激素受体（ER）状态分层时，ER（+）乳腺癌患者的 OR 范围为 0.782 至 0.844（95%CI，0.616-0.994，P<0.05），ER（-）乳腺癌患者的 OR 范围为 0.663 至 0.789（95%CI，0.498-0.991，P<0.05）。此外，癌症类型的 OR 值如下：子宫内膜癌为 1.577-1.908（95%CI，1.049-2.371，P<0.05）；高级别浆液性卵巢癌为 1.216-1.303（95%CI，1.021-1.591，P<0.05）；低级别恶性浆液性卵巢癌为 1.217（95%CI，1.034-1.432，P<0.05）；子宫内膜样卵巢癌为 1.502（95%CI，1.112-2.029，P<0.05）。此外，我们的研究结果表明，BMI 的遗传易感性与子宫肌瘤、宫颈癌前病变或宫颈癌本身之间不存在因果关联。
高 BMI 与多种女性生殖系统肿瘤及其相关亚型的高风险之间存在遗传关联。这突显了在 BMI 较高的女性中采取措施预防生殖系统肿瘤的重要性。
