Liu Bo, Zhang Yao, Yuan Zheng, Zhang Qiang
Department of Orthopaedics, Beijing Ditan Hospital, Capital Medical University, National Center for Infectious Diseases, Beijing, 100015, People's Republic of China.
Infect Drug Resist. 2024 Aug 14;17:3537-3545. doi: 10.2147/IDR.S474589. eCollection 2024.
is a zoonotic disease that can affect various organs, including the spine. Cervical spondylitis caused by is rare but can lead to significant morbidity if not diagnosed and treated promptly.
We report a case of a 46-year-old female who presented with intermittent high fever and intractable neck, shoulder, and back pain for two months. She was diagnosed with cervical spondylitis based on clinical manifestations, Rose-Bengal Plate Agglutination Test (RBPT, positive), and cervical MRI findings. She was treated with a combination of antibiotics for at least two weeks, followed by surgical intervention including abscess clearance, partial vertebral resection, and titanium mesh bone fusion. Real-time Polymerase Chain Reaction (RT-PCR) confirmed the presence of sheep DNA. The patient recovered well postoperatively with significant pain reduction and restoration of full mobility in the right upper limb.
This case highlights the diagnostic value of RT-PCR and tissue biopsy in cervical brucellosis spondylitis. Our study found that anterior cervical subtotal corpectomy can restore cervical stability, clear abscess, and relieve spinal cord compression on the basis of drug treatment, with good clinical results.
是一种人畜共患病，可累及包括脊柱在内的多个器官。由其引起的颈椎病虽罕见，但如不及时诊断和治疗可导致严重发病。
我们报告一例46岁女性，她出现间歇性高热以及颈部、肩部和背部顽固性疼痛达两个月。根据临床表现、虎红平板凝集试验（RBPT，阳性）以及颈椎MRI检查结果，她被诊断为布鲁氏菌性颈椎病。她接受了至少两周的联合抗生素治疗，随后接受了包括脓肿清除、部分椎体切除和钛网植骨融合在内的手术干预。实时聚合酶链反应（RT-PCR）证实存在羊布鲁氏菌DNA。患者术后恢复良好，疼痛明显减轻，右上肢完全恢复活动能力。
本病例突出了RT-PCR和组织活检在颈椎布鲁氏菌性脊柱炎中的诊断价值。我们的研究发现，颈椎前路次全椎体切除在药物治疗基础上可恢复颈椎稳定性、清除脓肿并缓解脊髓压迫，临床效果良好。
