Kaoje Yusuf Suleiman, Mokete Lipalo, Dafkin Chloe, Pietrzak Jurek, Sikhauli Khodi, Frimpong Emmanuel, Meiring Rebecca M
Movement Physiology Research Laboratory, University of the Witwatersrand, Johannesburg, South Africa.
Arthroplasty Unit, Division of Orthopaedic Surgery, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.
Disabil Rehabil. 2025 Apr;47(8):2097-2104. doi: 10.1080/09638288.2024.2390670. Epub 2024 Aug 20.
This study aimed to investigate the relationship between cardiometabolic disease risk and time spent in device-measured activity behaviours in a cohort of people with advanced osteoarthritis (OA) awaiting joint replacement surgery.
Cardiometabolic risk biomarkers were assessed in people with OA ( = 96; hip = 38, knee = 58; mean (SD) age = 64.3 (9.8) years; 71% female). Physical activity (PA) and sedentary behaviour (SB) were measured by accelerometer over seven days (24 h/day).
There were similar patterns of PA and SB between the hip and knee OA participants except for total number of steps (hip = 3365 (2926) vs knee 4344 (2836) steps/day; = 0.018) and total stepping time (hip = 50.8 (38.2) vs knee = 67.2 (38.5) min/day; = 0.005). Each additional cardiometabolic risk factor accumulated was associated with a 26.3 min/day increase in sedentary behaviour ( = 0.032; 95% CI: 2.3, 50.2), a 26.3 min/day decrease in upright time ( = 0.032; -50.2, -2.3) and a 23.6 min/day decrease in standing time ( = 0.032; -45.1, -2.1).
In people with hip or knee OA, increased cardiometabolic disease risk was associated with more sitting and less upright and standing time. Findings support targeting reductions in sedentary behaviour for improvements in cardiometabolic health in people with osteoarthritis. IMPLICATIONS FOR REHABILITATIONKnee and hip osteoarthritis is a condition which is associated with an increased risk of cardiometabolic disease but also due to the low levels of physical activity and high levels of sedentary behaviour.Offsetting sedentary behaviour with light physical activity offers a feasible interventional target to reduce the risk of cardiometabolic disease in people with hip and knee osteoarthritis.
本研究旨在调查等待关节置换手术的晚期骨关节炎（OA）患者队列中心血管代谢疾病风险与通过设备测量的活动行为所花费时间之间的关系。
对OA患者（n = 96；髋关节 = 38例，膝关节 = 58例；平均（标准差）年龄 = 64.3（9.8）岁；71%为女性）进行心血管代谢风险生物标志物评估。通过加速度计在七天内（每天24小时）测量身体活动（PA）和久坐行为（SB）。
髋关节和膝关节OA参与者之间的PA和SB模式相似，但步数总数（髋关节 = 3365（2926）步/天 vs 膝关节 = 4344（2836）步/天；P = 0.018）和总踏步时间（髋关节 = 50.8（38.2）分钟/天 vs 膝关节 = 67.2（38.5）分钟/天；P = 0.005）除外。累积的每一个额外心血管代谢风险因素都与久坐行为每天增加26.3分钟相关（P = 0.032；95%置信区间：2.3，50.2），与直立时间每天减少26.3分钟相关（P = 0.032；-50.2，-2.3），与站立时间每天减少23.6分钟相关（P = 0.032；-45.1，-2.1）。
在髋关节或膝关节OA患者中，心血管代谢疾病风险增加与更多的坐姿以及更少的直立和站立时间相关。研究结果支持以减少久坐行为为目标，以改善骨关节炎患者的心血管代谢健康。康复意义膝关节和髋关节骨关节炎是一种与心血管代谢疾病风险增加相关的疾病，同时也归因于身体活动水平低和久坐行为水平高。用轻度身体活动抵消久坐行为为降低髋关节和膝关节骨关节炎患者心血管代谢疾病风险提供了一个可行的干预目标。
