嵌合体和镶嵌型现象塑造了我们的体质，并影响着各种医疗状况。
Chimerism and mosaicism shape our physical constitution and impact medical conditions.
机构信息
Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Department of Pathology, Georgetown University Medical Center, Washington, District of Columbia, USA.
出版信息
Br J Haematol. 2024 Oct;205(4):1262-1264. doi: 10.1111/bjh.19705. Epub 2024 Aug 20.
Abstract
ABO blood group discrepancies in healthy individuals were caused by body-wide chimerism and mosaicism. They can be evaluated with new diagnostic options for disease-related cell clones that are typically associated with mosaicism. The observations raise the attention for sporadic mixed-field observations of any blood group antigen. Commentary on: Dauber et al. Body-wide chimerism and mosaicism are predominant causes of naturally occurring ABO discrepancies. Br J Haematol 2024; 205:1188-1196.
摘要
健康个体中的 ABO 血型不合是由全身性嵌合体和镶嵌现象引起的。可以使用与镶嵌现象相关的典型疾病相关细胞克隆的新诊断方法进行评估。这些观察结果引起了对任何血型抗原的散发性混合场观察的关注。述评：Dauber 等人。全身性嵌合体和镶嵌现象是自然发生的 ABO 差异的主要原因。英国血液学杂志 2024；205：1188-1196。
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