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针对 PI3K/AKT 和 MEK/ERK 通路以协同作用改善周围糖尿病神经病变的特征。

Targeting PI3K/AKT and MEK/ERK pathways for synergic effects on improving features of peripheral diabetic neuropathy.

机构信息

Faculty of Biology and Environment, Ho Chi Minh City University of Industry and Trade, Ho Chi Minh City, Vietnam.

出版信息

J Diabetes Investig. 2024 Nov;15(11):1537-1544. doi: 10.1111/jdi.14289. Epub 2024 Aug 20.

DOI:10.1111/jdi.14289
PMID:39162579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11527830/
Abstract

Diabetic neuropathy is one of the most serious and common complications of diabetes with a wide spectrum, affecting 30-50% of diabetic patients. However, the current treatments of this disorder, mainly based on controlling blood glucose level, show an inadequate clinical outcome. Better approaches are needed. In this fashion, it is noted that promoting nerve regeneration and preventing nerve degeneration should be focused on equally and appropriately. In this mini review, how more effective approaches are in targeting PI3K/AKT and MEK/ERK pathways in the treatment of peripheral diabetic neuropathy is discussed. Future treatment of peripheral diabetic neuropathy should consider these approaches.

摘要

糖尿病周围神经病变是糖尿病最严重和最常见的并发症之一，具有广泛的谱，影响 30-50%的糖尿病患者。然而，目前这种疾病的治疗主要基于控制血糖水平，临床效果并不理想。需要更好的治疗方法。因此，人们注意到，促进神经再生和防止神经退化应该同等重视并适当处理。在这篇综述中，讨论了如何通过更有效的方法来靶向治疗周围性糖尿病神经病变中的 PI3K/AKT 和 MEK/ERK 通路。未来治疗周围性糖尿病神经病变应考虑这些方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e99/11527830/0cccdced0e0b/JDI-15-1537-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e99/11527830/f0d81cde7a49/JDI-15-1537-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e99/11527830/0cccdced0e0b/JDI-15-1537-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e99/11527830/f0d81cde7a49/JDI-15-1537-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e99/11527830/0cccdced0e0b/JDI-15-1537-g001.jpg

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