淋巴细胞性食管炎与嗜酸性粒细胞性食管炎的临床特征、内镜检查结果及治疗效果比较
Clinical Characteristics, Endoscopic Findings, and Treatment Outcomes in Lymphocytic Esophagitis Compared With Eosinophilic Esophagitis.
作者信息
Visaggi Pierfrancesco, Savarino Edoardo, Del Corso Giulio, Herlihy Naoimh, Ghisa Matteo, Dunn Jason M, Marciano Emanuele, Wong Terry, Green Michael, de Bortoli Nicola, Zeki Sebastian
机构信息
Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Centre for Oesophageal Diseases, Guy's and St. Thomas Hospital, London, UK.
出版信息
Am J Gastroenterol. 2025 Feb 1;120(2):469-472. doi: 10.14309/ajg.0000000000003046. Epub 2024 Aug 20.
INTRODUCTION
Lymphocytic esophagitis (LyE) and eosinophilic esophagitis (EoE) are immune-mediated esophageal diseases. Clinical characteristics, endoscopic findings, and treatment outcomes of LyE were compared with EoE.
METHODS
This was an international retrospective study on adults enrolled at 3 centers in Europe. We recorded clinical characteristics and endoscopy findings at baseline and symptoms, histology, and endoscopy outcomes after treatment of patients with LyE and EoE.
RESULTS
Demographics, clinical presentation, comorbidities, and endoscopy findings were largely different in 35 patients with LyE compared with 59 patients with EoE. Proton pump inhibitor response was generally lower in LyE.
DISCUSSION
LyE is clinically different from EoE, but differences in treatment response need further investigation.
引言
淋巴细胞性食管炎（LyE）和嗜酸性粒细胞性食管炎（EoE）是免疫介导的食管疾病。对LyE和EoE的临床特征、内镜检查结果及治疗效果进行了比较。
方法
这是一项针对欧洲3个中心成年患者的国际回顾性研究。我们记录了LyE和EoE患者基线时的临床特征和内镜检查结果，以及治疗后的症状、组织学和内镜检查结果。
结果
35例LyE患者与59例EoE患者相比，人口统计学、临床表现、合并症和内镜检查结果有很大差异。LyE患者对质子泵抑制剂的反应通常较低。
讨论
LyE在临床上与EoE不同，但治疗反应的差异需要进一步研究。
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