Knoerl Robert, Sohn Michael B, Foust Melyssa, Francar Lori, O'Rourke Mark A, Morrow Gary M, Mustian Karen M, Gauthier Lynn, Gewandter Jennifer S
University of Michigan in Ann Arbor.
University of Rochester Medical Center.
Oncol Nurs Forum. 2024 Aug 15;51(5):445-450. doi: 10.1188/24.ONF.445-450.
To explore cancer survivors' historical and current use of analgesics for chronic chemotherapy-induced peripheral neuropathy (CIPN).
SAMPLE & SETTING: 142 post-treatment cancer survivors who received neurotoxic chemotherapy and were experiencing moderate to severe CIPN.
METHODS & VARIABLES: Participants completed the Treatment-Induced Neuropathy Assessment Scale at baseline and reported all analgesics used to manage CIPN. Frequency of historical or current prescription analgesic use for chronic CIPN was described and stratified by CIPN pain severity.
At baseline, 31% of participants reported historical use of analgesics for CIPN and 46% of participants were currently using analgesics for CIPN. Gabapentin was the most frequently used analgesic, historically (20%) and currently (34%), and duloxetine was used less frequently (6% historical use, 10% current use). Many participants with severe pain (59%) reported using analgesics for CIPN.
Duloxetine, the first-line treatment for chronic CIPN pain, was used less frequently than gabapentin, a common prescription analgesic for neuropathic pain. Further research is needed to determine strategies to promote the implementation of evidence-based CIPN treatments in clinical practice.
探讨癌症幸存者过去及目前使用镇痛药治疗慢性化疗引起的周围神经病变（CIPN）的情况。
142名接受过神经毒性化疗且患有中度至重度CIPN的癌症治疗后幸存者。
参与者在基线时完成治疗引起的神经病变评估量表，并报告所有用于治疗CIPN的镇痛药。描述慢性CIPN过去或目前使用处方镇痛药的频率，并按CIPN疼痛严重程度进行分层。
在基线时，31%的参与者报告过去曾使用镇痛药治疗CIPN，46%的参与者目前正在使用镇痛药治疗CIPN。加巴喷丁是过去（20%）和目前（34%）最常用的镇痛药，而度洛西汀的使用频率较低（过去使用6%，目前使用10%）。许多重度疼痛的参与者（59%）报告使用镇痛药治疗CIPN。
度洛西汀作为慢性CIPN疼痛的一线治疗药物，其使用频率低于加巴喷丁，后者是治疗神经性疼痛的常用处方镇痛药。需要进一步研究以确定在临床实践中促进实施循证CIPN治疗的策略。
