Zarnegar Arman, Valsecchi Nicola, Sadeghi Elham, Shah Stavan, Tang Anthony, Yagobian Shiva, Iannetta Danilo, Chhablani Jay
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ophthalmology Unit, Dipartimento Di Scienze Mediche E Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Graefes Arch Clin Exp Ophthalmol. 2025 Jan;263(1):59-67. doi: 10.1007/s00417-024-06611-w. Epub 2024 Aug 20.
Predicting the progression of intermediate AMD (iAMD) to neovascular AMD (nAMD) will help to identify high-risk patients and improve treatment outcomes. The present study assessed whether choroidal OCT biomarkers could predict conversion to nAMD.
This retrospective study included patients with clinically stable iAMD who either converted to nAMD (C group) or did not convert (NC group) during one year of follow-up. OCT parameters included subfoveal choroidal thickness (SFCT), central macular thickness (CMT), Haller vascular thickness (HVT), inner choroidal thickness (ICT), and double-layer sign (DLS).
Of 116 total eyes, there were 37 in the NC group and 79 in the C group. Baseline SFCT was significantly lower in the C group compared to the NC group (169.0 ± 63.2 μm vs. 218.0 ± 97.8 μm, p = 0.01). Baseline HVT and ICT were lower in the C group (105.2 ± 40.6 μm vs. 121.0 ± 56.6 μm, p = 0.17 and 61.9 ± 35.5 μm vs. 77.5 ± 41.7 μm, p = 0.09). HVT was decreased at all time points in the C group vs NC (p > 0.05). The ICT was reduced in the C group at each time point except at conversion time (p > 0.05). Of all eight eyes who presented DLS at baseline, 100% converted to nAMD (p < 0.001).
Lower SFCT at baseline may signal conversion to nAMD within 12 months.
预测中度年龄相关性黄斑变性（iAMD）进展为新生血管性年龄相关性黄斑变性（nAMD）将有助于识别高危患者并改善治疗效果。本研究评估脉络膜光学相干断层扫描（OCT）生物标志物是否能预测向nAMD的转变。
这项回顾性研究纳入了临床稳定的iAMD患者，这些患者在一年的随访期间要么转变为nAMD（C组），要么未转变（NC组）。OCT参数包括黄斑中心凹下脉络膜厚度（SFCT）、中心黄斑厚度（CMT）、哈勒血管层厚度（HVT）、内层脉络膜厚度（ICT）和双层征（DLS）。
在总共116只眼中，NC组有37只，C组有79只。与NC组相比，C组的基线SFCT显著更低（169.0±63.2μm对218.0±97.8μm，p = 0.01）。C组的基线HVT和ICT更低（105.2±40.6μm对121.0±56.6μm，p = 0.17；61.9±35.5μm对77.5±41.7μm，p = 0.09）。与NC组相比，C组在所有时间点的HVT均降低（p>0.05）。除转变时外，C组在每个时间点的ICT均降低（p>0.05）。在基线时出现DLS的所有8只眼中，100%转变为nAMD（p<0.001）。
基线时较低的SFCT可能预示在12个月内转变为nAMD。
