Department of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea; and.
Nun Seeone Eye Clinic, Busan, Korea.
Retina. 2021 Feb 1;41(2):409-422. doi: 10.1097/IAE.0000000000002845.
To evaluate topographic changes in choroidal thickness during development of choroidal neovascularization (CNV) in treatment-naive age-related macular degeneration (AMD) and to test the value of such changes as a predictive tool of CNV development.
This retrospective cohort included 86 eyes that developed CNV from intermediate AMD, 43 eyes with intermediate AMD, and 36 eyes without AMD. Patients with intermediate AMD underwent spectral domain optical coherence tomography using enhanced depth imaging mode every 6 months until CNV was detected. Choroidal neovascularization was localized to one of the subfields of Early Treatment of Diabetic Retinopathy Study grid on fluorescein angiography. Average choroidal thickness of each subfield was calculated.
Choroidal thickness of the subfield where CNV developed at first clinical detection significantly increased compared with that 6 months before (P = 0.000 for central, P = 0.001 for superior parafoveal, P = 0.002 for temporal parafoveal, P = 0.002 for inferior parafoveal, and P = 0.001 for nasal parafoveal subfield). In eight patients who visited unexpectedly 3 months before CNV development in central subfield, choroidal thickness of central subfield increased significantly compared with that 6 months before CNV development (P = 0.001).
Choroidal neovascularization development accompanied choroidal thickening of the corresponding subfield. Regular measurement of choroidal thickness may assist in prediction of CNV.
评估未经治疗的年龄相关性黄斑变性（AMD）脉络膜新生血管（CNV）发展过程中脉络膜厚度的地形变化，并验证这些变化作为 CNV 发展预测工具的价值。
本回顾性队列研究纳入了 86 只出现 CNV 的初发 AMD 眼、43 只进展为 CNV 的中间型 AMD 眼和 36 只无 AMD 的对照眼。中间型 AMD 患者每 6 个月接受一次频域光学相干断层扫描（SD-OCT），采用增强深度成像（EDI）模式，直至发现 CNV。CNV 在荧光素眼底血管造影（FFA）中定位于早期糖尿病视网膜病变研究（ETDRS）网格的一个亚区。计算每个亚区的平均脉络膜厚度。
初次临床发现 CNV 的亚区脉络膜厚度与 6 个月前相比显著增加（中央亚区 P = 0.000，上方旁中心亚区 P = 0.001，颞侧旁中心亚区 P = 0.002，下方旁中心亚区 P = 0.002，鼻侧旁中心亚区 P = 0.001）。在 8 例中央亚区 CNV 提前 3 个月就诊的患者中，CNV 前 6 个月的中央亚区脉络膜厚度与 CNV 前 6 个月相比显著增加（P = 0.001）。
CNV 的发生伴随着相应亚区脉络膜的增厚。定期测量脉络膜厚度可能有助于预测 CNV。
