无重原子的三重态苯并噻吩稠合 BODIPY 衍生物，用于脂滴特异性生物成像和光动力治疗。
Heavy-atom-free triplet benzothiophene-fused BODIPY derivatives for lipid droplet-specific biomaging and photodynamic therapy.
机构信息
The Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, School of Physics and Electronic Information, Anhui Normal University, Wuhu 241002, China.
College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005, China.
出版信息
Chem Commun (Camb). 2024 Sep 5;60(72):9809-9812. doi: 10.1039/d4cc02551b.
The twist fusion of a benzothiophene group and the introduction of a 4-methyloxystyryl donor group to the BODIPY core resulted in large spin-orbit coupling values and smaller singlet-triplet energy gaps for the novel infrared absorbed photosensitizers named BSBDP. They show a high reactive oxygen species efficiency exceeding 69% and a fluorescence quantum yield of 23% and are successfully applied in imaging-guided photodynamic therapy and .
苯并噻吩基团的扭曲融合以及将 4-甲氧基苯乙烯供体基团引入 BODIPY 核心，导致新型红外吸收光敏剂 BSBDP 的自旋轨道耦合值较大，单重态-三重态能隙较小。它们显示出超过 69%的高效活性氧物种效率和 23%的荧光量子产率，并成功应用于成像引导的光动力治疗 和 。
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