Senior Resident, Department of Critical Care Medicine, King Edward Memorial (KEM) Hospital, Pune, Maharashtra, India.
Assistant Professor, Department of Critical Care Medicine, Dr D Y Patil Medical College, Hospital and Research Centre, Dr D Y Patil Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
J Assoc Physicians India. 2024 Aug;72(8):44-47. doi: 10.59556/japi.72.0616.
Sepsis-linked biomarkers and inflammatory cytokines are markedly associated with potential risks of progression to severity in coronavirus disease 2019 (COVID-19). Clinical studies that find a plausible association between sepsis biomarkers and the inflammatory cytokine response in the Indian community need to be studied with clarity.
To study the relationship between sepsis-linked biomarkers and inflammatory cytokines interleukin-6 (IL-6), C-reactive protein (CRP), ferritin, and D-dimer linked to clinical severity resulting from COVID-19 infection.
The present prospective observational cohort study was conducted between March and December 2021 in the Department of Critical Care Medicine at a tertiary care hospital in Pune, Maharashtra, India, on COVID-19 patients. Upon patient admission, inflammatory biomarkers such as IL-6, CRP, ferritin, and D-dimer were recorded. Oxygen requirements during hospitalization, invasive mechanical ventilation (IMV), high-flow nasal cannula (HFNC), noninvasive mechanical ventilation (NIV), duration of ventilator use, intensive care unit (ICU) stay, and mortality were documented.
The average levels of IL-6, CRP, D-dimer, and serum ferritin protein recorded at the time of patient arrival were notably higher in the severe (S) group compared to the nonsevere (NS) group. The average duration of ventilator use, ICU stay, and hospital stay was significantly longer in the S group than in the NS group. The percentage of patients who required HFNC, NIV, IMV, and mortality was significantly higher in the S group compared to the NS group.
Sepsis-linked biomarkers and inflammatory cytokines such as IL-6, CRP, D-dimer, and serum ferritin levels at the time of admission were markedly associated with severity outcomes in COVID-19 infection.
脓毒症相关生物标志物和炎症细胞因子与 2019 年冠状病毒病（COVID-19）严重程度进展的潜在风险显著相关。需要对在印度人群中发现脓毒症生物标志物与炎症细胞因子反应之间存在合理关联的临床研究进行明确研究。
研究 COVID-19 感染导致的临床严重程度与脓毒症相关生物标志物和炎症细胞因子白细胞介素 6（IL-6）、C 反应蛋白（CRP）、铁蛋白和 D-二聚体之间的关系。
本前瞻性观察队列研究于 2021 年 3 月至 12 月在印度马哈拉施特拉邦浦那的一家三级护理医院的重症监护医学科进行，纳入 COVID-19 患者。患者入院时记录炎症生物标志物，如 IL-6、CRP、铁蛋白和 D-二聚体。记录住院期间的氧气需求、有创机械通气（IMV）、高流量鼻导管（HFNC）、无创机械通气（NIV）、呼吸机使用时间、重症监护病房（ICU）停留时间和死亡率。
与非严重组（NS 组）相比，严重组（S 组）患者到达时记录的平均 IL-6、CRP、D-二聚体和血清铁蛋白水平显著更高。S 组患者呼吸机使用时间、ICU 停留时间和住院时间的平均时间明显长于 NS 组。S 组患者需要 HFNC、NIV、IMV 和死亡率的百分比明显高于 NS 组。
入院时脓毒症相关生物标志物和炎症细胞因子，如 IL-6、CRP、D-二聚体和血清铁蛋白水平与 COVID-19 感染的严重程度结局显著相关。
