Assistant Professor, Department of Neurology, MS Ramaiah Medical College, Ramaiah University of Applied Sciences (RUAS), Bengaluru, Karnataka, India, Corresponding Author.
Senior Resident, Department of Neurology, MS Ramaiah Medical College, Ramaiah University of Applied Sciences (RUAS), Bengaluru, Karnataka, India.
J Assoc Physicians India. 2024 Aug;72(8):78-79. doi: 10.59556/japi.72.0615.
Gabapentin is the most commonly preferred agent for neuropathic pain in general practice as it is usually well tolerated, but occasionally, its toxicity may occur at standard doses, especially in elderly individuals, even without any prior comorbidities.
We present an elderly male with normal renal parameters, who was started on gabapentin for neuropathic pain. He developed multifocal myoclonus all over the body within few days after starting gabapentin and subsided completed after withdrawal of the drug.
Acute hyperkinetic movement disorders such as multifocal or segmental myoclonus in elderly patients warrant a prompt review of recent drug history, especially gabapentin, even in the background of normal renal function.
加巴喷丁通常是一般实践中治疗神经病理性疼痛的首选药物，因为它通常耐受性良好，但偶尔在标准剂量下也会出现毒性，尤其是在老年人中，即使没有任何先前的合并症。
我们介绍了一位老年男性，他的肾功能参数正常，开始使用加巴喷丁治疗神经病理性疼痛。他在开始使用加巴喷丁后几天内全身出现多灶性肌阵挛，停药后完全缓解。
老年人急性多动性运动障碍，如多灶性或节段性肌阵挛，需要及时审查近期药物史，特别是在肾功能正常的情况下也要考虑加巴喷丁。
