Resident, Department of Rheumatology, P D Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra, India, Corresponding Author.
Consultant Pulmonologist , Department of Pulmonary Medicine, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India.
J Assoc Physicians India. 2024 Aug;72(8):93-95. doi: 10.59556/japi.72.0530.
Granulomatosis with polyangiitis (GPA) is a pauci-immune vasculitis typically involving upper and lower respiratory tract involvement and crescentic glomerulonephritis. Salivary gland involvement in GPA is rare. When it occurs in GPA, it is commonly seen with sinonasal and lung involvement and rarely with renal involvement. Easy accessibility of salivary glands allows early biopsy and timely treatment. In our case with GPA, salivary gland involvement was unresponsive to cyclophosphamide but remitted with rituximab.
肉芽肿性多血管炎（GPA）是一种寡免疫血管炎，通常累及上呼吸道和下呼吸道，伴新月体性肾小球肾炎。GPA 很少累及唾液腺。当 GPA 累及唾液腺时，常与鼻旁窦和肺部受累相关，很少与肾脏受累相关。唾液腺易于获取，可进行早期活检和及时治疗。在我们的 GPA 病例中，虽然环磷酰胺治疗无效，但利妥昔单抗治疗后缓解。
