Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States.
Mayo Clinic School of Graduate Medical Education, Rochester, MN, United States.
JMIR Dermatol. 2024 Aug 20;7:e54302. doi: 10.2196/54302.
Cellulitis is a bacterial skin infection that tends to recur. Previous studies have identified several risk factors that may contribute to its pathogenesis. Obesity is an increasingly prevalent worldwide disease that has been associated with skin and soft tissue infections.
The aim of our systematic review and meta-analysis was to investigate the association of cellulitis with obesity.
The Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Web of Science databases were searched for the relevant studies from the inception of each respective database to March 13, 2021. Case-control, cross-sectional, or cohort studies that examined the odds or risk of increased BMI in patients with cellulitis were included. This study was carried out in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The Newcastle-Ottawa scale (NOS) was used to evaluate the risk of bias in included studies.
In total, 9 case-control studies were included in our quantitative meta-analysis with a total of 68,148 study participants. A significant association was found between cellulitis and obesity (pooled odds ratio [OR] 2.67, 95% CI 1.91-3.71). No significant association was observed between cellulitis and being overweight (pooled OR 1.69, 95% CI 0.99-2.88). Patients with cellulitis were also found to have 1.63-fold increased odds of being male (pooled OR 1.63, 95% CI 1.12-2.38).
Our findings suggest that cellulitis is significantly associated with obesity. Maintaining a healthy BMI may be indicated for patients presenting with cellulitis.
蜂窝织炎是一种易复发的细菌性皮肤感染。先前的研究已经确定了一些可能导致其发病机制的风险因素。肥胖是一种在全球范围内日益流行的疾病，与皮肤和软组织感染有关。
我们的系统评价和荟萃分析旨在调查蜂窝织炎与肥胖的关系。
我们在 Ovid MEDLINE、Embase、Cochrane 中央对照试验注册库和 Web of Science 数据库中进行了检索，从每个数据库的创建日期到 2021 年 3 月 13 日，查找了相关研究。纳入了研究蜂窝织炎患者 BMI 增加的比值比或风险的病例对照、横断面或队列研究。本研究按照 PRISMA（系统评价和荟萃分析的首选报告项目）指南进行。使用纽卡斯尔-渥太华量表（NOS）评估纳入研究的偏倚风险。
共有 9 项病例对照研究纳入我们的定量荟萃分析，共纳入 68148 名研究参与者。蜂窝织炎与肥胖之间存在显著关联（合并比值比[OR]2.67，95%CI1.91-3.71）。蜂窝织炎与超重之间没有显著关联（合并 OR 1.69，95%CI0.99-2.88）。还发现蜂窝织炎患者男性的可能性增加了 1.63 倍（合并 OR 1.63，95%CI1.12-2.38）。
我们的研究结果表明，蜂窝织炎与肥胖有显著关联。对于出现蜂窝织炎的患者，保持健康的 BMI 可能是必要的。
