Department of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Indore, India.
MRC Centre for Inflammation Research, Queen'sMedicalResearch Institute, University of Edinburgh, Edinburgh, EH164TJ, UK.
Int Immunopharmacol. 2024 Nov 15;141:112938. doi: 10.1016/j.intimp.2024.112938. Epub 2024 Aug 18.
Alcoholic liver disease (ALD) is a broad category of disorders that begin with liver injury, lead to liver fibrosis, and ultimately conclude in alcohol-induced liver cirrhosis, the most chronic and irreversible liver damage. Liver fibrosis (LF) is a common pathological characteristic observed in most chronic liver inflammatory conditions that involve prolonged inflammation. In this review, we have summarized ethanol-mediated hepatic stellate cell (HSCs) activation and its role in liver fibrosis progression. We highlight important molecular mechanisms that are modulated by ethanol, play a role in the activation of HSCs and the progression of liver fibrosis and identifying potential targets to ameliorate liver fibrosis.
酒精性肝病（ALD）是一类广泛的疾病，其起始于肝损伤，导致肝纤维化，最终导致酒精性肝硬化，这是最常见的慢性和不可逆转的肝损伤。肝纤维化（LF）是大多数慢性肝脏炎症性疾病中观察到的一种常见的病理特征，涉及长期炎症。在这篇综述中，我们总结了乙醇介导的肝星状细胞（HSCs）激活及其在肝纤维化进展中的作用。我们强调了乙醇调节的重要分子机制，这些机制在 HSCs 的激活和肝纤维化的进展中发挥作用，并确定了改善肝纤维化的潜在靶点。
