Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA; Center for Combat and Battlefield (COMBAT) Research, University of Colorado School of Medicine, Aurora, CO, USA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Am J Surg. 2024 Dec;238:115887. doi: 10.1016/j.amjsurg.2024.115887. Epub 2024 Aug 3.
The risks associated with blood product administration and venous thromboembolic events remains unclear. We sought to determine which blood products were associated with the development of deep vein thrombosis (DVT) and pulmonary embolism (PE).
We analyzed data from patients ≥18 years of age in the Trauma Quality Improvement Program (TQIP) database that received ≥1 blood product and survived ≥24 h.
There were 42,399 that met inclusion, of whom, 2086 had at least one VTE event. In our multivariable logistic regression model, we found that WB had a unit odds ratio (uOR) of 1.05 (95 % CI 1.02-1.08) for DVT and 1.08 (1.05-1.12) for PE. Compared to WB, platelets had a higher uOR for DVT of 1.09 (1.04-1.13) but similar uOR for PE of 1.08 (1.03-1.14).
We found an association of both DVT and PE with early whole blood and platelets.
与血液制品输注和静脉血栓栓塞事件相关的风险仍不清楚。我们试图确定哪些血液制品与深静脉血栓形成（DVT）和肺栓塞（PE）的发展有关。
我们分析了创伤质量改进计划（TQIP）数据库中≥18 岁且接受≥1 个血液制品且存活≥24 小时的患者的数据。
共有 42399 名符合纳入标准的患者，其中至少有 1 例 VTE 事件。在我们的多变量逻辑回归模型中，我们发现 WB 的 DVT 单位优势比（uOR）为 1.05（95%CI 1.02-1.08），PE 的 uOR 为 1.08（1.05-1.12）。与 WB 相比，血小板的 DVT 优势比更高，为 1.09（1.04-1.13），但 PE 的 uOR 相似，为 1.08（1.03-1.14）。
我们发现 DVT 和 PE 与早期全血和血小板均有关联。
