O'Doherty M J, Page C J, Croft D N, Bateman N T
Nucl Med Commun. 1985 Jun;6(6):353-7. doi: 10.1097/00006231-198506000-00007.
In order to measure regional lung 'leakiness' we have adapted a method developed by Jones et al., to correct for background in the estimation of regional lung transfer of DTPA. It is clear from our study that the half time transfer values (T50) alter from the apex to the base of the lungs in both smokers and nonsmokers. The mean apical T50 values are 56.0 and 56.7 min for the right and left lung respectively in nonsmokers and 12.5 and 12.6 min in smokers. The basal T50 values are 77.5 and 76.9 min for the right and left lung respectively in nonsmokers and 24 and 24.2 min in smokers. These figures suggest that cigarette smoke affects all lung regions and that the transfer values in the apices are more rapid than in the bases in both smokers and nonsmokers.
为了测量局部肺的“渗漏性”，我们采用了琼斯等人开发的一种方法，以校正DTPA局部肺转运估计中的背景值。从我们的研究中可以清楚地看出，无论是吸烟者还是非吸烟者，肺从尖部到基部的半衰期转运值（T50）都会发生变化。非吸烟者右肺和左肺的平均尖部T50值分别为56.0分钟和56.7分钟，吸烟者为12.5分钟和12.6分钟。非吸烟者右肺和左肺的基部T50值分别为77.5分钟和76.9分钟，吸烟者为24分钟和24.2分钟。这些数据表明，香烟烟雾会影响所有肺区域，并且在吸烟者和非吸烟者中，尖部的转运值都比基部更快。
