改善帕金森病患者的执行功能和双重任务成本：一项随机对照试验。
Improving Executive Function and Dual-Task Cost in Parkinson Disease: A Randomized Controlled Trial.
机构信息
Department of Physical Therapy and Assistive Technology (J.-H.Z., R.-Y.W., S.-J.C., H.-H.L., Y.-R.Y) and Department of Neurology, School of Medicine (Y.-T.L.), National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology (Y.-T.L.), Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology (S.-J.C.), Mackay Memorial Hospital, Taipei, Taiwan; and Department of Physical Therapy (H.-H.L.), Chung Shan Medical University, Taichung City, Taiwan.
出版信息
J Neurol Phys Ther. 2024 Oct 1;48(4):188-197. doi: 10.1097/NPT.0000000000000489. Epub 2024 Sep 17.
BACKGROUND AND PURPOSE
Dual-task walking is challenging for people with Parkinson disease (PD). Gait performance worsens while executing dual tasks, possibly due to a decline in executive function (EF). This study aimed to investigate the effects of dual-task training on EF and dual-task cost (DTC) in people with PD and to explore whether training-induced changes in EF were associated with changes in DTC.
METHODS
This study was a randomized controlled trial. A total of 28 people with PD participated. Participants were randomly assigned to the experimental group (dual-task training) and the control group (treadmill training). Both groups received a total of 16 training sessions during the 8 weeks. Assessments were conducted at baseline and postintervention. Primary outcomes included EF and dual-task cost.
RESULTS
Significant time-by-group interactions were found in executive function and DTC. The experimental group showed significant improvement in frontal assessment battery (FAB), trail-making test (TMT) part A, Stroop color and word test (SCWT), and DTC on speed in cognitive dual-task walking. There was a moderate to high correlation between the change values of the FAB, TMT part A, SCWT, and the change values of DTC in cognitive dual-task walking.
DISCUSSION AND CONCLUSIONS
Compared to treadmill training, dual-task training resulted in greater improvements in EF and DTC. Training-induced changes in EF were linked to changes in DTC when walking while performing a cognitive task but not when walking while performing a motor task.
VIDEO ABSTRACT
For more insights from the authors Supplemental Digital Content available at http://links.lww.com/JNPT/A485.
背景与目的
双重任务行走对帕金森病（PD）患者具有挑战性。在执行双重任务时，步态表现会恶化，这可能是由于执行功能（EF）下降所致。本研究旨在探讨双重任务训练对 PD 患者 EF 和双重任务成本（DTC）的影响，并探讨 EF 训练诱导的变化是否与 DTC 的变化相关。
方法
这是一项随机对照试验。共有 28 名 PD 患者参与。参与者被随机分配到实验组（双重任务训练）和对照组（跑步机训练）。两组在 8 周内共接受了 16 次训练。在基线和干预后进行评估。主要结局包括 EF 和双重任务成本。
结果
EF 和 DTC 均存在显著的时间-组间交互作用。实验组在额叶评估量表（FAB）、连线测试（TMT）A 部分、斯特鲁普色词测验（SCWT）和认知双重任务行走的 DTC 速度方面均有显著改善。FAB、TMT 部分 A、SCWT 的变化值与认知双重任务行走的 DTC 变化值之间存在中度至高度相关性。
讨论与结论
与跑步机训练相比，双重任务训练在 EF 和 DTC 方面的改善更为显著。EF 的训练诱导变化与认知任务下行走时的 DTC 变化相关，但与运动任务下行走时的 DTC 变化无关。
视频摘要
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